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安糖Ⅰ号方治疗2型糖尿病早期肾病临床疗效观察 被引量:1

Clinical Research on Treatment of Early Type-2 Diabetic Nephropathy with Antang Ⅰ Decoction
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摘要 目的观察安糖Ⅰ号方对早期糖尿病肾病(diabetic nephropathy,DN)的临床疗效。方法将60例早期糖尿病肾病患者随机分为治疗组及对照组,每组30例。治疗组予安糖Ⅰ号方口服,对照组予西药羟苯磺酸钙治疗,疗程均为8周。观察两组患者治疗前后临床证候积分、空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白A1c(glycosylated hemoglobin A1c,GHbA1c)、肾脏彩色多普勒血流信号、尿清蛋白分泌量(urine albumin excretion,UAE)、稳态模型评估胰岛素抵抗(homeostasis model assessment insulin re-sistance,HOMA-IR)指数变化。结果安糖Ⅰ号方在改善临床症状积分、肾脏彩色多普勒血流信号、UAER、HOMA-IR方面优于对照组;两组治疗后FBG、GHbA1c无显著性差异。结论安糖Ⅰ号方能改善早期DN临床症状,其作用机制可能不是直接降低血糖,而是与改善胰岛素抵抗等作用相关。 Objective To observe the clinical effects of Antang Ⅰ Decoction, a prescription of traditional Chinese medicine, in the treatment of early type-2 diabetic nephropathy (DN). Methods Sixty cases of early DN were averagely randomized into treatment group and control group. Patients in treatment group were treated with Antang Ⅰ Decoction, one dose daily, and patients in control group with Calcium Dobesilate Capsule, 500 mg, three times daily. A course of treatment was 8 weeks. Before and after treatment, clinical symptoms, fasting blood glucose (FBG) level,glycosylated hemoglobin A1c (GHbA1c), the renal color Doppler flow signals, urinary albumin excretion(UAE) and homeostasis model assessment insulin resistance (HOMA-IR) in both groups were observed. Results There was significant difference between treatment group and control group in clinical efficacy including the renal color Doppler flow signals, UAER and HOMA-IR;The FBG and HbA1c in all patients significantly decreased after treatment, while there was no significant difference between the two groups. Conclusion Antang Ⅰ Decoction can amelioratesymptoms and signs of early DN. Its mechanism might not directly correlate with reducing the level of blood glucose, but with other pathways such as improving insulin resistance.
出处 《安徽中医学院学报》 CAS 2010年第1期17-20,共4页 Journal of Anhui Traditional Chinese Medical College
关键词 糖尿病肾病 安糖Ⅰ号方 中医药疗法 Diabetic nephropathy Antang Ⅰ Decoction Therapy of traditional Chinese medicine
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参考文献4

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