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盐酸法舒地尔防治蛛网膜下腔出血后脑血管痉挛疗效观察 被引量:2

Clinical observation on treating cerebral vasospasm following subarachnoid hemorrhage with fasudil hydrochloride
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摘要 目的:观察和评价盐酸法舒地尔防治蛛网膜下腔出血后脑血管痉挛的疗效。方法:选择我院近年来收治的蛛网膜下腔出血后脑血管痉挛病人42例,随机分为治疗组20例和对照组22例,对照组在常规治疗基础上给以尼莫地平注射治疗,治疗组在常规治疗上给以盐酸法舒地尔注射治疗,观察两组患者治疗前后大脑中动脉血流速度,显效、有效、无效患者数及不良反应。结果:治疗组,总有效率为95%,对照组的为71.4%,治疗组不良反应发生例数少于对照组。结论:盐酸法舒地尔防治蛛网膜下腔出血后脑血管痉挛的疗效比较好。
出处 《中医临床研究》 2010年第4期45-46,共2页 Clinical Journal Of Chinese Medicine
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  • 1Nakamura K,Nishimura J,Hirano K,et al.Hydroxyfasudil,an active metabolice of fasudil hydrochloride,relaxes the rabbit basilar artery by disinibition of myosin light chain phosphatase.J Cereb Blood Flow Metab,2001,21:876-885.
  • 2Masumoto N,Tanabe Y,Saito M,et al.Attenuation of pressure-induced myogenic contraction and tyrosine phosphorylation by fasudil,a cerebral vasodilator,in rat cerebral artery.British journal of pharmacology,2000,130:219-230.
  • 3Takanashi Y,Ishida T,Meguro T,et al.A novel drug delivery system as prophylaxis for cerebral vasospasm.Acta Neurochir,2001,(Suppl) 77:213-215.
  • 4Masaoka H,Takasato Y,Nojiri T,et al.Clinic effect of fasudil hydrochloride for cerebral vasospasm following subarachnoid hemorrhage.Acta Neurochir,2001,(Suppl) 77:209-221.
  • 5Miriam M T,Bernhard W,Peter M S,et al.Systematic review of the prevention of delayed ischemic neurological deficits with hypertension,hypervolemia,and hemodilution therapy following subarachnoid hemorrhage.J Neurosurg,2003,98:978-984.
  • 6Nagumo H,Sasaki Y,Ono Y,et al.Rho-kinase inhibitor HA-1077 prevents rho-mediated myosin phosphatase inhibition in smooth muscle cells.Am J Physiol,2000.278:C57-C65.
  • 7Sasaki Y,Suzuki M,Hidaka H.The noval and specific rhokinase inhibitor (s)-(+) -2-Methyl-1-[(4-methyl-5 -isoquinoline) sulfony] -Homopiperazine as a probing molecule for rho-kinase-invlved pathway.Phrmacology & Therapeutics,2002,93:225-232.
  • 8Satoh Sh,Suzuki I,Ikegaki I,et al.The effects of HA 1077on the cerebral circulation after subarachnoid haemorrhage in dogs.Acta Neurochir (Wien),1991,110:185-188.
  • 9Shibuya M,Suzuki Y,Sugita K,et al.Effect of AT877 on cerebral vasospasm after aneurysmal subaracnoid hemorrhage.J Neurosurg,1992,76:571-577.
  • 10Shibuya M,Asano T,Sasaki Y.Effect of fasudil HCl,a protein kinase inhibitor,on cerebral vasospasm.Acta Neurochir,2000,(Suppl) 77:201-204.

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