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RAAS激活与急性心肌梗死早期新发房颤的关系 被引量:6

Relationship between activation of renin-angiotensin-aldosterone system and new-onset atrial fibrillation in early phase of acute myocardial infarction
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摘要 目的探讨急性心肌梗死(AMI)早期新发房颤(AF)患者肾素—血管紧张素—醛固酮系统(RAAS)的变化及二者之间的关系。方法选择AMI发病24 h内且为窦性心律的患者80例,根据患者住院期间是否发生房颤分为AF组和非AF组,记录年龄、体质量指数(BMI)、心血管相关病史,检测血浆肾素、血管紧张素、醛固酮水平,同时常规检查血常规、高敏C反应蛋白(hsCRP)及心脏彩超等。结果AF组患者年龄、BMI、合并糖尿病人数均高于非AF组,肾素、血管紧张素、醛固酮水平升高且左房增大(P均<0.05)。结论RAAS激活可能对AMI早期新发AF的预测有重要意义。 Objective To investigate the role of renin-angiotensin-aldosterone system (RAAS) in new-onset atrial fibrillation (AF) in early phase of acute myocardial infarction (AMI). Methods A total of 80 AMI patients with sinus rhythm within 24 hours after chest pain onset while admission were enrolled and divided into two groups by whether AF occurred or not during hospitalization. The baseline clinical data including age, body mass index and past history related cardiovascular diseases were obtained. Venous blood samples were obtained to detect renin, angiotensin, aldosterone and high sensitivity C-reactive protein (hsCRP) within 24 hours of AMI. All patients underwent echocardiographic examination. Results AF patients were older and overweight and had a longer history of diabetes mellitus and larger left atrial diameter (P 〈 0.05 ). RAAS levels were higher in patients with AF than those without AF ( P 〈 0.05 ). Conclusion It might be useful to measure RAAS for the predicting of new-onset AF in early phase of AMI.
出处 《山东医药》 CAS 北大核心 2010年第4期26-28,共3页 Shandong Medical Journal
关键词 心肌梗塞 心房颤动 肾素 血管紧张素类 醛固酮 myocardial infarction atrial fibrillation rennin angiotensins aldosterone
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参考文献9

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