摘要
目的探讨无创正压通气（NIPPV）治疗慢性阻塞性肺疾病急性加重期（AECOPD）并Ⅱ型呼吸衰竭的临床疗效。方法62例慢性阻塞性肺疾病（COPD）急性加重期合并Ⅱ型呼吸衰竭患者，随机分为对照组32例，治疗组30例。对照组经常规药物治疗；治疗纽在上述常规治疗基础上加间歇NIPPV治疗。比较2组治疗前后动脉血气[血的酸碱度（pH值）、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）]及血乳酸变化。结果2组治疗后24h血气分析[pH为7．36±0．05和7．34±0．03、PaO2为84．0±8．9和53．0±12．4、PaCO2为57．0±7．9和62．0±9．4]及血乳酸[（1．63±1．15）和（2．54±1．28）]比较差异均有统计学意义（P均〈0．05）。结论NIPPV是治疗COPD急性加重期合并Ⅱ型呼吸衰竭的有效方法。
Objective To assess the effect of non-invasive positive pressure ventilation （NIPPV） in treating acute exacerbation of chronic obstructive pulmonary disease （AECOPD） complicated with type Ⅱ respiratory failure. Methods Sixty-two AECOPD patients complicated with type 11 respiratory failure was randomly divided into two groups ： treated group of 30 patients and control group of 32 patients. The control group was treated with regular medicine, the treated group were treated with NIPPV additional to regular medicine. The pH value, PaO2, PaCO2 and lactic acid level in blood gas were measured before and after treatment. Results The level of PH, PaO2, PaCO2 and lactic acid at 24 hours after treatment in the treated groups were 7.36 （ SD ：0.05 ） ,84.0 （ SD ： 8.9 ） ,57.0 （ SD ：7.9 ） and 1.63 （ SD ： 1.15 ） respectively, which were significantly different to those of the control group （ 7.34 [ SD ：0.03 ] ,53.0 [ SD ： 12.4 ], 62.0 [ SD ：9.4 ] and 2.54 [ SD ： 1.28 ], respectively） （ P 〈 0.05 ）. Conclusinons NIPPV is effective in treating patients with AECOPD and type 11 respiratory failture.
出处
《中国综合临床》
2010年第3期260-262,共3页
Clinical Medicine of China
关键词
无创正压通气
慢性阻塞性肺疾病
Ⅱ型呼吸衰竭
血气分析
血乳酸
Non-invasive positive pressure ventilation
Chronic obstructive pulmonary diseases
Type Ⅱ respiratory failure
Blood gas analysis
Lactic acid
