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植物表观遗传中的RNA介导的DNA甲基化 被引量:5

RNA-dependent DNA Methylation in Plant Epigenomics
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摘要 植物基因组对基因的表达调控不仅表现在转录水平上,也表现在染色质结构的变化上。在植物中存在着特有的RNA聚合酶Ⅳ(RNA PolⅣ)和RNA聚合酶Ⅴ(RNA PolⅤ),它们与RNA聚合酶Ⅱ(RNA PolⅡ)相似。RNAPolⅣ和RNAPolⅤ的转录产物包括参与表观遗传调控的长链非编码RNA(lncRNAs)和干扰小RNA(siRNAs)。这类非编码RNA广泛地参与了基因组上发生的胞嘧啶甲基化,去甲基化以及甲基化扩散。近年来,研究已经发现RNA介导的染色质水平的基因沉默涉及植物的生长发育、胁迫应答、表观遗传多态性,并对植物的表型多样化、生理适应性以及植物进化具有显著影响。 In plant genome,gene expression often depends on transcriptional regulation and chromatin structure conversion.RNA polymerase Ⅳ and RNA polymerase Ⅴ,two RNA polymerase II-related RNA polymerases,are specific in plant.Their transcriptional production includes long non-coding RNA and small interfering RNA,broadly involved in methylation or demethylation of cytosine and spreading of methylation on plant genome.Recently,research showed that RNA-mediated and chromatin-based gene silence are involved in plant growth and development,stress response and epigenetic polymorphism.It is exerting evident influences on plant phenotypic diversity,physiological adaptability and evolutional change.
出处 《中国农业科技导报》 CAS CSCD 2009年第6期7-13,共7页 Journal of Agricultural Science and Technology
基金 国家973计划项目(2006CB101601) 绿洲生态农业重点实验室开放课题发展基金(200704)资助
关键词 表观遗传 RNA聚合酶 干扰小RNA(siRNA) RNA介导的DNA甲基化(RdDM) DNA甲基化 epigenomic RNA polymerase small interfering RNA(siRNA) RNA-directed DNA methylation(RdDM) DNA methylation
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  • 1Buhter M. RNA lurnover and chromatin-dependent gene silencing [ J ]. Chromosoma,2009,118 ( 2 ) : 141 - 151.
  • 2Chekanova J A, Gregory B D, Reverdatto S V, et al.. Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis Cell,2007,131 (7) :1340 - 1353.
  • 3Zilberman D, Gehring M, Tran R K, et al.. Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription [ J ]. Nat. Genet. ,2007,39(1 ) :61 -69.
  • 4Lippman Z, Gendrel A V, Black M, et al.. Role of transposable elements in heterochromatin and epigenetic control [ J ]. Nature, 2004,430 ( 6998 ) :471 - 476.
  • 5Zhang X, Yazaki J, Sundaresan A, et al.. Genome-wide highresolution mapping and functional analysis of DNA methylation in Arabidopsis[J]. Cell ,2006,126(6) :1189 - 1201.
  • 6Lister R, O' Malley R C, Tonti-Filippini J, et al.. Highly integrated single-base resolution maps of the epigenome in Arabidopsis[J]. Cell,2008,133(3) :523 -536.
  • 7Pikaard C S, Haag J R, Ream T, et al.. Roles of RNA polymerase Ⅳ in gene silencing[ J ]. Trends Plant Sci. ,2008, 13 (7) :390 -397.
  • 8Wierzbicki A T, Haag J R, Plkaard C S. Noneoding transcription by RNA polymerase Pol Ⅳb/Pol Ⅴ mediates transcriptional silencing of overlapping and adjacent genes [ J ]. Cell, 2008, 135(4) :635 -648.
  • 9El-Shami M, Pontier D, Lahmy S, et al.. Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components [ J]. Genes Dev. ,2007,21 (20) :2539 - 2544.
  • 10Zheng X, Zhu J, Kapoor A, et al.. Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylatiun and transcriptional gene silencing[ J]. EMBO ,2007,26 (6) : 1691 - 1701.

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