摘要
目的:探讨非痴呆帕金森病(PD)患者轻度认知障碍与发病年龄和疾病阶段的关系。方法:将120例非痴呆PD患者按年龄分为年轻组(<60岁,65例)和老年组(≥60岁,55例),再按照病程分为年轻早期非痴呆PD组(33例)、年轻晚期非痴呆PD组(32例)、老年早期非痴呆PD组(27例)和老年晚期非痴呆PD组(28例)。将60例正常人按年龄分为年轻对照组(34例)和老年对照组(26例)。分别采用简明精神量表(MMSE)、Fuld物体记忆测验(FOM)、语言流畅性测验(RVR)、积木测验(BD)和数字广度测验(DS)评定神经心理学功能。结果:①按照年龄分组,年轻正常对照组与年轻早期非痴呆PD组及年轻晚期非痴呆PD组间各神经心理学评分差异无统计学意义(P>0.05),而老年正常对照组与老年早期非痴呆PD组及老年晚期非痴呆PD组间MMSE、FOM、RVR、BD及DS评分差异有统计学意义(F分别为4.972、5.015、5.078、4.891和4.943,P均<0.05)。按照疾病阶段分组,年轻早期非痴呆PD组与老年早期非痴呆PD组间各神经心理学评分差异无统计学意义(P>0.05),而年轻晚期非痴呆PD组与老年晚期非痴呆PD组间MMSE、FOM、RVR、BD及DS评分差异均有统计学意义(t分别为2.734、2.926、2.972、2.773和2.741,P均<0.05)。②检出51例(42.5%)轻度认知功能障碍的非痴呆PD(PD-MCI)患者,多因素回归分析显示非痴呆PD-MCI患者与认知正常的非痴呆PD患者相比年龄更大,起病更晚,运动损害更为严重。结论:非痴呆PD患者存在认知功能的下降。在非痴呆PD患者中筛查出PD-MCI患者有着重要的临床意义。PD-MCI的发生与非痴呆PD患者年龄和疾病阶段有关。
Aim：To explore the relationship between mild congnitive impairment（MCI） in non-demented Parkinson＇s disease（PC-MCI） and the age of onset and the stage of this illness.Methods：The cognitive functions were assessed by MMSE,FOM,RVR,BD and DS in 120 PD patients（33 young early stage PD patients,27 old early stage PD patients,32 young advanced stage PD patients,and 28 old advanced stage PD patients） and 60 normal subjects（34 cases of young controls and 26 cases of old controls）.Results：①No significant differences in neuropsychology scores were recorded among the young early stage PD patients,young controls and the young advanced stage PD patients（P0.05）.However,significant differences in neuropsychology scores were recorded among the old early PD patients,old controls and the old advanced stage PD patients（F=4.972,5.015,5.078,4.891,and 4.943;P0.05）.No significant differences in neuropsychology scores were recorded between the young early stage PD patients and the old early stage PD patients（P0.05）,however,significant differences of neuropsychology were recorded between the young advanced stage PD patients and the old advanced stage PD patients（t=2.734,2.926,2.972,2.773,and 2.741;P0.05）.②51（42.5%）PD patients were diagnosed as PD-MCI and compared with those without cognitive impairment,the result showed the subjects with PD-MCI were older,and motor impairments were more serious.Conclusion：Cognition decline exists in non-demented PD patients.It is important in clinic to identify the PD-MCI from non-demonted PD patients.The occurrence of PD-MCI is related to the onset age and the stage of this disease.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2010年第1期84-87,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
帕金森病
轻度认知障碍
患病率
年龄
Parkinson ＇ s disease
mild cognitive impairment
prevalence
age
