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EGCG对胃癌细胞增殖以及RECK基因表达的影响 被引量：4

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摘要 目的研究表没食子儿茶素没食子酸酯(EGCG)对胃癌细胞MGC803细胞增殖以及对RECK基因mRNA表达的影响。方法用不同浓度的EGCG刺激体外培养的MGC803细胞,MTT检测其增值情况,RT-PCR检测RECK mRNA的表达。结果EGCG能以剂量依赖性方式抑制MGC803细胞的增值,当浓度为50μM时抑制率达39.4%;且富于72h后能明显诱导RECK mRNA的表达。结论EGCG能抑制肿瘤细胞增殖,其机制可能与诱导RECK基因表达有关。
作者 毛振江 李国庆 黄靓 钟鹰
机构地区 湖南省衡阳市南华大学附二医院消化内科
出处 《当代医学》 2010年第4期41-42,共2页 Contemporary Medicine
关键词 表没食子儿茶素没食子酸酯(EGCG) MGC803 RECK
分类号 R735.2 [医药卫生—肿瘤] R737.25 [医药卫生—肿瘤]
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参考文献6

  • 1Chung FL,Schwartz J,Herzog CR,et al.Tea and cancer prevention:studies in animals and humans[J].J Nutr.2003 Oct,133(10):3268S-3274S.
  • 2Takahashi C,Sheng Z,Horan TP,et al.Regulation of matrix metalloproteinase-9 and inhibition of tumor irwasion by the membrane-anchored glycoprotein RECK[J].Proc Natl Acad Sci U S A.1998 Oct 27,95(22):13221-6.
  • 3Mosmann T.Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays[J].J Immunol Methods,1983 Dec 16,65(1-2):55-63.
  • 4Yokozawa T,Nakagawa T,Kitani K.Antioxidative activity of green tea polyphenol in cholesterol-fed rats[J].J Agric Food Chem,2002 Jun 5,50(12):3549-52.
  • 5季润元,冯振卿.KAI1基因与肿瘤侵袭、转移、预后的关系[J].医学研究生学报,2004,17(10):949-951. 被引量：7
  • 6Shaw RJ,Hall GL,Lowe D,et al.CpG island methylation phenotype(CIMP)in oral cancer:associated with a marked inflammatory response and less aggressive tumour biology[J].Oral Oncol.2007 Oct,43(9):878-886.

二级参考文献16

  • 1[1]Dong JT, Lamb PW, Rinker SCW et al. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2[J]. Scinece, 1995, 268(5):884-886.
  • 2[2]Jean M. New clue to prostate cancer Spread[J]. Scinece, 1995, 268(5):799-800.
  • 3[3]Dong JT, Isaacs WB,Barrett JC et al. Genomic organization of the human KAI1 metastasis suppressor gene[J]. Genomics, 1997, 41:25-32.
  • 4[4]Bouras T, Frauman AG. Expression of the prostate cancer metastasis suppressor gene KAI1 in primary prostate cancer: a biphasic relationship with tumor grade[J]. J Pathol, 1999,188(4): 382-388.
  • 5[6]Adachi M, Taki T, Ieki Y et al. Correlation of KAI1/CD82 gene expression with good prognosis in patients with non-small cell lung cancer[J]. Cancer Res, 1996,56(8):1751-1755.
  • 6[7]Higashiyama M, Kodama K, Yokouchi H et al. KAI1/CD82 expression in nonsmall cell lung carcinoma is a novel, favorable prognostic factor: an immunohistochemical analysis[J]. Cancer, 1998, 83(3):466-474.
  • 7[9]Guo XZ, Friess H, Di Mola FF et al. KAI1, a new metastasis suppressor gene, is reduced in metastasis hepatocellular carcinoma[J]. Hapatology, 1998, 28(6):1481-1488.
  • 8[11]Yang X, Welch DR, Phillips KK et al. KAI1, a putative marker for metastasis potential in human breast cancer[J]. Cancer Lett, 1997, 119:149-155.
  • 9[13]Guo XZ, Friess H, Graber HU et al. KAI1 expression is up-regulation in early pancreatic cancer and decreased in the presence of metastasis[J]. Cancer Res, 1996, 56(21):4876-4880.
  • 10[15]Uchida S, Shimada Y, Watanabe G et al. Motility-related protein (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastasis in oesophageal squamous cell carcinoma[J]. Br J Cancer, 1999, 79(7-8):1168-1173.

共引文献6

同被引文献88

引证文献4

二级引证文献10

当代医学
2010年 第4期

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