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静脉内应用替罗非班对急性心肌梗死介入治疗预后的影响

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摘要 目的探讨急性ST段抬高心肌梗死急诊PCI时静脉内应用国产替罗非班对冠状动脉灌注与临床预后影响的差异。方法连续选择60例急性ST段抬高心肌梗死拟行急诊PCI的患者,随机分为替罗非班应用组(n=30)与非替罗非班应用组(n=30)比较两组术后即刻造影结果、住院期间主要不良心脏事件(MACE)发生的差异。结果共有59例完成试验,其中男性46例,女性13例,年龄35~85(60.80±13.17)岁,替罗非班组在术后心外膜TIMI分级、心电图ST段回落、梗死相关血管远端末栓塞、以及治疗后1周内的心脏彩超射血分数值方面均显著优于非替罗非班组,两组院内MACE事件发生差异无显著性,平均住院日也基本相同。替罗非班组发生轻度出血与严重出血并发症及血小板减少症的发生率方面有增多的趋势,但差异无显著性。结论对于急性ST段抬高心肌梗死行急诊PCI治疗的患者,应用替罗非班安全、有效,与非替罗非班应用组相比,可以进一步改善冠脉再灌注状态并能提高临床预后。
出处 《中国城乡企业卫生》 2010年第1期30-32,共3页 Chinese Journal of Urban and Rural Enterprise Hygiene
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