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血小板膜糖蛋白Ⅱb/Ⅲa受体与子痫前期 被引量：1

Relationship Between Platelet Membrane Glycoprotein Ⅱb/Ⅲa Receptor and Preeclampsia
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摘要 糖蛋白Ⅱb/Ⅲa(glycoproteinⅡb/Ⅲa,GPⅡb/Ⅲa)受体是血小板膜上最丰富的一种蛋白,在血小板聚集、血栓形成过程中起关键性调节作用。子痫前期是一种病因不明伴有多系统功能障碍的病理妊娠,表现为高血压、蛋白尿、高凝血、高纤溶倾向,是围产期孕产妇死亡的主要原因,又是产妇远期并发心脑血管疾病的高危因素。GPⅡb/Ⅲa受体在子痫前期发病过程中起"承前启后"的调节作用,有可能为子痫前期的病因探索、临床治疗提供新的突破。 GPⅡb/Ⅲa receptor is the most redundant glycoprotein on platelet membrane,and palys a critical role in the process of platelet aggregation and thrombosis.Preeclampsia is a pathogestation with polysystem imbalance,characterized with hypertension,proteinuria,hypercoagulation,hyperfibrinolysis tendency,and is associated with high maternal high morbidity and mortality and parturient cardiovascular and cerebrovascular disorders in long term.GPⅡb/Ⅲa receptor is a key component in the process of preeclampsia invasion,which could provide original breakthrough for its etiopathogenisis and clinical therapy.
作者 程淑清 黄亚绢
机构地区 上海市第六人民医院妇产科
出处 《国际妇产科学杂志》 CAS 2010年第1期27-30,共4页 Journal of International Obstetrics and Gynecology
关键词 糖蛋白Ⅱb/Ⅲa 整合素αⅡbβ3 子痫前期 血栓形成 Glycoprotein Ⅱb/Ⅲa Integrin αⅡbβ3 Preeclampsia Thrombosis
分类号 R714.245 [医药卫生—妇产科学]
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参考文献20

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同被引文献14

  • 1王晓霞,李晓钟,刘红林,解军,张悦红,王惠珍,牛勃.AoGDW肽抑制血小板聚集的作用机制[J].中国药理学通报,2007,23(5):626-629. 被引量：8
  • 2Sanchez-Cortes J, Mrksich M. The platelet integrin αⅡ b133 binds to the RGD and AGD motifs in fibrinogen [J]. Chem Biol, 2009,16 (9): 990-1000.
  • 3Comisar WA, Mooney DJ, Linderman JJ. lntegrin organiztion: linking adhesion ligand nanopatterns wittl altered cell responses [J]. J Ther Biol, 2011. 274 (1): 120-130.
  • 4Calvete J J, Marcinkiewicz C, Munle6n D, et al. Snake wmom disintegrins: evolution of" structure and function [J]. Toxicon, 2005, 45 ( 8 ) : 1063-1074.
  • 5Szemraj J, Zakrzeska A, Brown G, et al. New derivalive of staphylokinase SAK-RGD-K2-Hirul exerts thrnmbolytic effects in the arterial thrombosis model in rats [J]. Phannacol Rep, 2011, 63 (5): 1169-1179.
  • 6Jones ML, Harper MT, Aitken EW, et ol. RGD-ligand mime- tic antagonists of integrin alphalIbbeta3 paradoxically enhance GPVI-induced human platelet activation [J]. J Thromb Hae- most, 2010, 8 (3): 567-576.
  • 7Zhang JG, Kra jden OB, Kainthan RK, et all. Conjugation to hyperbranched polyglycerols improves RGD-mediated inhibi- tion of platelet function in vitro [J]. Bioconjug Chem, 2008, 19 (6): 1241-1247.
  • 8Ahrens IG, Moran N, Aylward K, et ol. Evidence for a differential functional regulation of the twoβ3-integrins αVβ and aⅡbβ3 [J]. Exp Cell Res, 2006, 312 (6): 925-937.
  • 9Russo MA, Paolillo M, Sanchez-Hernandez Y, et al. A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells [J]. Int J Oncol, 2013, 42 (1): 83-92.
  • 10Chen ZY, Deng JX, Zhao Y, et al. Cyclic RGD peptide- modified liposomal drug delivery system: enhanced cellular uptake in vitro and improved pharmacokinetics in rats [J]. Int J Nanomedicine, 2012, 7 (3): 3803-3811.

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国际妇产科学杂志
2010年 第1期

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