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抗血小板治疗新进展 被引量:6

New antiplatelet therapies in development
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摘要 众所周知,血小板在动脉系统血栓形成中起着关键作用,抗血小板治疗已成为预防和治疗动脉系统血栓的基石。目前临床主要应用的抗血小板药物有阿司匹林、二磷酸腺苷(ADP)受体拮抗剂及Ⅱb/Ⅲa受体拮抗剂,在传统抗血小板药物的基础上,新的药物也在不断研发。但是,抗血小板治疗现状仍不理想,在临床抗血小板获益的同时,其局限性及治疗的特异性还存在诸多问题。本文拟以此为中心,结合抗血小板治疗的最新进展进行相关讨论。
作者 王明晓 朱琳
出处 《中国心血管病研究》 CAS 2010年第3期232-235,共4页 Chinese Journal of Cardiovascular Research
关键词 抗血小板治疗 阿司匹林 氯吡格雷 Ⅱb/Ⅲa受体拮抗剂 Antiplatelet therapy Aspirin Clopidogrel Glycoprotein Ⅱb/Ⅲa inhibitors
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  • 1Taylor DW, Barnett H J, Haynes RB, et al. Low-dose and highdose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomized controlled trial: ASA and Carotid Endarterectomy (ACE) Trial collaborators. Lancet, 1999,353 : 2179-2184.
  • 2朱正炎,胡大一.阿司匹林抵抗及其发生机制(一)[J].中国心血管病研究,2004,2(10):755-756. 被引量:11
  • 3Gum PA,Kottke MK,Poggio ED,et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am J Cadio, 2001,88 : 230-235.
  • 4Mehta SR, Yusuf S, Peters R J, et al. For the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trim Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention:the PCI-CURE study. Lancet,2001,358: 527-533.
  • 5Steinhubl SR,Berger PB,Mann III JT,et al. For the CREDO Investigators. Clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial ( CREDO ). JAMA, 2002,288: 2411-2420.
  • 6Bhatt DL, Fox KA, Haeke W,et al. For the Clopidogrel for High Atherothrombotie Risk and Ischemie Stabilization, Management, and Avoidance (CHARISMA) Investigators. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med,2006,354: 1706-1717.
  • 7Muller I, Besta F, Schulz C, et al. Prevalence of clop idogrel non- responders among patientswith stable angina pectofis scheduled for elective coronary stent placement. Thromb Haemost, 2003,89: 7832-7871.
  • 8Softer D, Moussa I, Harjai KJ, et al. Impact of angina class on inhibition of p latelet aggregation following clop idogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina? Catheter Cardiovasc Interv, 2003,59 : 212-251.
  • 9Aleil B, Ravanat C, Cazenave JP,et al. Flow cytometric analysis of intrap latelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseasesl. J Thromb Haemost, 2005,3 : 852-921.
  • 10Serebruany VL,Steinhubl SR,Berger PB,et al. Variability in platelet responsiveness to clop idogrel among 544 individuals. J Am Coll Cardiol, 2005,45 : 2462-2511.

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