摘要
目的观察缬沙坦联合丹参注射液治疗早期糖尿病肾病(DN)的疗效。方法将212例DN患者随机分为对照组和治疗组,对照组102例,给予缬沙坦80mg/d;治疗组110例,在缬沙坦治疗的基础上给予丹参注射液20ml静脉滴注,每日1次,2周为1个疗程。每3个月给予1个疗程的治疗,共治疗18个月。观察治疗前后尿白蛋白排出量(UAE)和血清C反应蛋白(CRP)水平的变化。结果2组治疗后UAE均下降(P〈0.05,P〈0.01),且组间比较差异有显著性(P〈0.01)。疗程结束后,治疗组血清CRP降低(P〈0.01)。对照组降低不明显(P〉0.05),组间比较差异有显著性(P〈0.01)。结论缬沙坦与丹参注射液联合应用可减少UAE、降低血清CRP水平,对早期糖尿病肾病有较好的肾脏保护作用。
Objective To investigate the effect of Valsartan combined with Salvia Injection on the early Diabetic Nephropathy(DN). Method 212 patients with DN were randomly divided into two groups: the control group and the treatment group. 102 patients in control group received Valsartan 80mg/per day, while 110 patients in treatment group received additional 20 ml Salvia Injection by intravenous injection. Both of two groups were treated for 18 months, once a day,two weeks for one course and one course every three months. The changes of Urinary Albumin Excretion( UAE )and serum C-reactive protein(CRP) level were observed before and after theraphy. Results After the treatment, the UAE of the both groups wasdecreased ( P 〈 0.05, P 〈 0.01 ) and there was significant difference ( P 〈 0.01 ) between two groups. The C RP in the treatment group decreased(P 〈0.01 ) ,while there was no change in the control group(P 〉0.05). Significant difference between the two groups was found ( P 〈 0.01 ). Conclusion Valsartan combined with Salvia Injection can reduce UAE and CRP level and has protective effects against early diabetic nephropathy.
出处
《临床内科杂志》
CAS
2010年第2期91-93,共3页
Journal of Clinical Internal Medicine
关键词
糖尿病肾病
微量尿白蛋白
C反应蛋白
丹参注射液
缬沙坦
Diabetic nephropathy
Urinary albumin excretion
C-reactive protein
Salvia injection
Valsartan