摘要
p38通路是真核细胞转导细胞外信号到细胞内引起细胞反应的一类重要信号通路,它能够调控多种细胞内分子事件。p38是p38通路发挥生物学作用的末端激酶,它能够通过调控MyoD、Myf-5活性或表达、组蛋白修饰、染色体重塑、某些细胞分化相关mRNA的更替等方式影响肌肉分化进程。运动能够激活p38,p38可能通过NF-κB/IL-6/成肌调节因子(myogenic regulatory factor,MRF)及肌细胞专一增强因子2(muscle-specific enhancement factor2,MEF2)、过氧化物增殖物活化受体γ辅激活因子1α(peroxisome proliferator activated receptor γ coactivator-1α,PGC-1α)、葡萄糖转运蛋白4(glucose transporter 4,GLUT4)在运动介导的肌肉发生、线粒体发生、血糖摄取能力提高等几方面发挥作用。
p38 signal pathway is a important kind of signal pathway which can transfer extracellular signal into cell and regulate cellular molecular events, p38 is the end kinase of p38 signal pathway which can effect muscle cell differentiation by regulating activity or expression of MyoD, Myf-5, histone modification, chromosome remodeling and turnover of some mRNA related with muscle cell differentiation. Acute exercise can activate p38. p38 can effect exercise-induced Inyogenesis, mitochondriogenesis and glucose uptake increase by NF-κB/IL-6/MRF, MEF2, PGC-1α, GLUT4.
出处
《生命的化学》
CAS
CSCD
北大核心
2010年第1期22-26,共5页
Chemistry of Life
基金
吉林省体育局课题基金(2007D11)
佛山科技学院2007年课题基金(20071206)资助
