摘要
目的:探讨紫杉醇(PTX)或多西他赛(TXT)与氟尿嘧啶(5-FU)/或顺铂(DDP)(简称PCF或DCF方案)治疗进展期胃癌(AGC)的疗效及安全性和生存情况。方法:60例AGC患者根据不同化疗方案分为2组。PCF组30例,PTX35～50mg·m-2,3h静脉滴注,第1、8、15天;5-FU750mg·m-2,持续静脉滴注,第1～5天;DDP20mg·m-2,2h静脉滴注,第1～5天。DCF组30例,TXT35mg·m-2,1h静脉滴注,第1、8、15天;5-FU及DDP用量、用法与PCF组相同。化疗周期均为28d,2周期后评判近期疗效、安全性,持续随访远期疗效。结果:PCF组总有效率(ORR)50.0%,疾病控制率(DCR)66.6%,中位生存期(MST)10.4个月,1年生存率35.7%;DCF组ORR46.6%,DCR63.3%;MST9.6个月、1年生存率34.4%;2组近远期疗效比较无显著性差异(P>0.05)。2组Ⅲ～Ⅳ级毒副反应主要为中性粒细胞减少、恶心呕吐及脱发。Ⅳ级中性粒细胞减少及贫血总发生率,DCF组显著高于PCF组(P<0.05)。结论:PCF方案与DCF方案治疗AGC,疗效和生存情况相似,毒副反应有差别,但均可耐受。
OBJECTIVE： To investigate the efficacies and safety of paclitaxel （PTX） versus Taxotere （TXT） and fluorouracil （5-FU） versus cisplatin （DDP） （PCF vs. DCF regimens） in the treatment of advanced gastric cancer （AGC）. METHODS： 60 cases of AGC were divided into two groups according to different regimens. The patients in group PCF （n= 30） received 35-50 mg. m^-2 PTX via ivgtt for 3 hours on the 1st, 8th, 15th day. The patients in group DCF （n=30） received 35 mg·m^-2 TXT via ivgtt for 1 hour, on the 1 st, 8th, 15th day. Both groups were given 750 mg·m^-2 5-FU with continuous infusion administration from the 1st to 5th day and 20 mg·m^-2 DDP via ivgtt for 2 hours from the 1st to 5th day with treatment course of 28 d. Recent efficacy and safety were evaluated after two cycle of treatment and long-term efficacy were followed up continuously. RESULTS： Overall response rate （ORR） was 50.0% for group PCF and 46.6% for group DCF. Disease control rate （DCR） was 66.6% in group PCF and 63.3% in group DCF. The median survival time （MST） was 10.4 months in group PCF and 9.6 months in group DCF. One-year survival rates were 35.7% for group PCF and 34.4% for group DCF. There was no statistically significance in recent and long-term efficacy between two groups. Grade Ill/IV toxicities represented as bone marrow depression, nausea, vomiting and alopecia in two groups. Grade IV neutropenia and the overall incidence of anemia, DCF was significantly higher than the PCF group. CONCLUSION： PCF and DCF regimens have similar response in the treatment of advanced gastric cancer. Drug toxicity of two regimes are different while both of them are tolerable well.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第8期715-717,共3页
China Pharmacy
关键词
紫杉醇
多西他赛
胃癌
化疗
Paclitaxel
Taxotere
Gastric cancer
Chemotherapy
