摘要
目的:探讨生脉注射液联合地塞米松在心肺复苏(CPR)中的疗效及对超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的影响。方法:488例心脏骤停患者随机分为试验组150例和对照组338例。对照组采用国际标准进行基础CPR,试验组在对照组的基础上,按照1mg·kg-1生脉注射液加入5%葡萄糖注射液250mL静脉滴注。分别在10、30、60、120min采静脉血检测CPR成功的患者的SOD活性及MDA含量。结果:试验组有17例抢救成功,CPR成功率为11.33%;对照组有22例抢救成功,CPR成功率为6.50%。试验组SOD活性升高明显快于对照组,MDA含量降低也快于对照组;2组SOD活性及MDA含量比较差异有统计学意义(P<0.05)。结论:生脉注射液联合地塞米松在CPR中具有较好疗效,能显著增强SOD活性,降低MDA含量。
OBJECTIVE： To evaluate the effect of Shengmai injection and dexamethasone on the activity of SOD and the content of MDA during cardiopulmonary resuscitation. METHODS ： 538 patients with cardiac arrest were randomly divided into experiment group and control group. Both groups were carried out cardiopulmonary resuscitation according to 1NT rule. Experiment group were additionally treated with 1 mg·kg^-1 dexamethasone, 1 mg·kg^-1 Shengmai injection and 5% glucose injection （250 mL） via i. v gtt. 39 cases who were successfully rescued were respectively detected in terms of the activity of SOD and content of MDA in venous blood at 10 min, 30 min, 60 min and 120 min. RESULTS ： The success ratio of cardiopulmonary resuscitation in experiment group and control group were 11.33% and 6.50%, respectively. The activity of SOD in experiment group were higher than in control group while The content of MDA in experiment group were lower than in control group（P〈0.05）. CONCLUSION： Shengmai injection and dexarnethasone have significant therapeutic effect on cardiopulmonary resuscitation.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第8期737-739,共3页
China Pharmacy
关键词
地塞米松
生脉注射液
心肺复苏
Dexamethasone
Shengmai injection
Cardiopulmonary resuscitation
