摘要
目的:评价3种用药方案治疗幽门螺杆菌感染的成本-效果。方法:将150例幽门螺杆菌阳性的消化性溃疡患者随机分为3组,每组50例,分别服用兰索拉唑+克拉霉素+阿莫西林(A组)、雷贝拉唑+阿莫西林+甲硝唑(B组)、奥美拉唑+克拉霉素+阿莫西林(C组),疗程均为7d,比较临床疗效并进行成本-效果分析。结果:A、B、C3组成本分别为120.19、62.02、120.75元,幽门螺杆菌感染根除率分别为82%、92%、80%,成本-效果比分别为146.57、67.41、150.94;A、C组方案相对于B组方案的增量成本-效果比分别为523.50,440.50。结论:与其他2组方案比较,B组方案为治疗幽门螺杆菌感染的较佳方案。
OBJECTIVE： To evaluate the cost-effectiveness of three drug regimes for infection of Helicobacter Pylori （Hp）. METHODS： 150 patients with peptic ulcer infected by positive Hp were randomly assigned to three groups. They were treated with Lansoprazole, Clarithromycin and amoxicillin （group A, n=50）, Rabeprazole, amoxicillin and metronidazole （group B, n=50） or omeprazole, Clarithomycin and amoxicillin （group C, n=50）, respectively with course of treatment as 7 days. The observation of clinical efficacy and analysis of cost-effectiveness were conducted. RESULTS： In group A, B, C, the costs were 120.19, 62.02, 120.75 yuan; the eradication of Hp was 82%, 92%, 80%; ratio of cost-effectiveness was 146.57, 67.41, 150.94, respectively; incremental costs were 523.50,440.50. CONCLUSION： The regime for Hp in group B is the best one among 3 groups.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第8期758-759,共2页
China Pharmacy
关键词
质子泵抑制剂
用药方案
幽门螺杆菌
成本-效果分析
Proton pump inhibitor
Drug regime
Helicobacter Pylori
Cost-effectiveness analysis
