摘要
目的探讨血糖波动对2型糖尿病周围神经病变的影响。方法对202例2型糖尿病患者进行Michigan糖尿病神经病变症状评分、体征评分和神经电生理检测,根据血糖变异系数分为持续性高血糖组和波动性高血糖组,分析不同糖化血红蛋白(HbA1C)水平时两组周围神经病变发生情况和严重程度。结果 HbA1C≥9%时,波动性高血糖组神经病变发生率(44.9%)、Michigan糖尿病神经病变症状评分(2.42±2.38)和体征评分(1.76±1.45)均高于持续性高血糖组(分别为30.4%,0.60±0.83,0.80±1.39),差别有统计学意义(P<0.05);腓总感觉神经传导速度[左侧(50.91±5.14)m/s,右侧(51.38±5.98)m/s]和腓总运动神经传导速度[左侧(45.72±4.53)m/s,右侧(44.90±3.56)m/s]低于持续性高血糖组[分别为左侧(54.13±5.82)m/s,右侧(54.43±5.27)m/s和左侧(47.17±3.66)m/s,右侧(47.40±3.57)m/s],差别有统计学意义(P<0.05)。结论波动性高血糖增加2型糖尿病患者周围神经病变的发生率和严重性。
bjective To research the relationship between fluctuating high glucose and peripheral neuropathy in type 2 diabetes mellitas （T2DM）. Methods 202 of T2DM patients were examined with Michigan diabetic neuropathy symptom score, sign score and nerve electrophysiological test, patients in T2DM were divided into 2 groups according to glucose coefficient of variability, constant high glucose group and fluctuating high glucose group. Results When HbAlc ~〉9%, the prevalence of peripheral neuropathy （44.9%）, Michigan diabetic neuropathy symptom score （2.42±2.38） and sign score （1.76±1.45） in fluctuating high glucose group were much higher than those in constant high glucose group （30.4%, 0.60±0.83 and 0.80±1.39） （all P〈0.05）; common peroneal sensory nerve conduction velocity （50.91±5.14 in left, 51.38±5.98 in right）and common peroneal motor nerve conduction velocity （45.72±4.53 in left, 44.90±3.56 in right） in fluctuating high glucose group were much lower than those （54.13± 5.82 in left, 54.43±5.27 in right and 47.17±3.66 in left, 47.40±3.57 in right） in constant high glucose group （all P〈O.05）. Conclusion Fluctuating high glucose may increase occurence and severity of peripheral neuropathy in patients with T2DM.
出处
《中国慢性病预防与控制》
CAS
北大核心
2010年第1期54-56,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
