摘要
目的观察腹膜透析对慢性肾功能衰竭(肾衰)营养不良患者指标的影响。方法按SGA评分方法选择75例存在营养不良的慢性肾衰患者,包括非透析组患者30例、腹膜透析组患者45例,对照组30例为健康志愿者;对所有入选者测定营养不良相关指标血红蛋白(Hb)、血清尿素氮(BUN)、肌酐(SCr)、白蛋白(ALB)、前白蛋白(PA)、转铁蛋白(TF)、胆固醇(CH),炎症相关指标超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及血清胰岛素样生长因子-1(IGF-1)、瘦素(Leptin)。结果腹膜透析组和非透析组与对照组比较,除CH外,其余指标均具有明显差异(P<0.01或0.05);而腹膜透析组与非透析组相比较,血清PA、TF、ALB、TNF-α、Leptin、IGF-1具有明显差异,余指标无明显差异。结论腹膜透析患者的营养不良程度较非透析患者更加严重,应积极进行干预和治疗。
Objective It is to observe the effects of peritoneal dialysis on indexes in malnutrition patients with chronic renal failure. Methods 75 cases of patients with renal failure including 30 cases of non-peritoneal dialysis and 45 cases of peri- toneal dialysis were chosen according to SGA score method. 30 cases of healthy volunteers were chosen as control group. Cor- related indexes of malnutrition Hb, BUN, SCr, ALB, PA, TF and CH, correlated indexes of inflammation hs- CRP, IL- 6, TNF- α, and serum IGF- 1, Leptin were determined in all the objects. Results Compared with the control group, there were significant differences in all the indexes above except CH in non-peritoneal dialysis group and peritoneal dialysis group （P〈0.05 or 0.01）. There were significant differences in serum PA,TF, ALB, TNF- α, Leptin and IF- 1 and no dif- ferences in the other index between non-peritoneal dialysis group and peritoneal dialysis group. Conclusion Degrees of malnu- trition in patients accepted peritoneal dialysis were more serious than that of non-peritoneal dialysis group ones, so construc- tive intervention and treatment should be carried on.
出处
《现代中西医结合杂志》
CAS
2010年第10期1185-1186,1226,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
腹膜透析
慢性肾功能衰竭
营养不良
peritoneal dialysis
chronic renal failure
malnutrition
