摘要
目的评价胰腺实性假乳头状瘤(SPTP)的临床表现、诊断、治疗和预后。方法对空军总医院肝胆外科自1995年10月至2009年4月收治的5例SPTP患者临床资料进行回顾性分析。结果肿瘤标本切面均为灰红或灰褐色,肿瘤的平均直径为(7.5±2.2)cm,均为囊实性肿物,内含咖啡色液体,内壁粗糙。5例肿瘤标本在显微镜下均具有SPTP的典型病理学表现:形态单一的多边形肿瘤细胞围绕纤维血管轴排列成不规则假乳头状结构,并有部分细胞脱落,细胞核为圆形或椭圆形,无明显异形,部分胞核核膜皱缩有核沟,胞浆内含有嗜酸性颗粒。全组无围手术期死亡,5例中4例术后恢复顺利,1例行胰体尾+脾切除术患者术后出现胰瘘,经给予持续腹腔引流、生长抑素静脉滴注、抗感染、营养支持等治疗,3周后恢复正常。随访期间均未发现肿瘤复发转移迹象。结论SPTP是一种罕见的低度恶性肿瘤,好发于青年女性,手术切除后预后良好。
Objective To evaluate the clinical presentations, diagnosis, treatment and prognosis of solid-pseudopapillary tumor of the pancreas （SPTP）. Methods Five patients with SPTP managed between October 1995 and April 2009 in air force general hospital were reviewed. Results Tumor specimen cut noodles were ash red or beige, the mean diameter of the tumors was （ 7.5 ± 2.2 ） cm. Bladders of the tumors were solid and rough. Five cases tumor specimen showed typical pathologic manifestation of SPTP by microscope. Polygon tumor cells of form single around fiber vascular axial arranged to irregular false papillary structure, and some cell fell off, circular or oval nucleolus, without obvious abnormity. Part of nucleolus shrunk and had nuclear ditch,the cytoplasm contained eosinophilic granular. There was no perioperative death, four patients recovered smoothly postoper- ative, one patient with resection of pancreatic body tail ＋ spleen appeared pancreatic fistula postoperative,the treatment of continued abdominal cavity water-spreading, somatostatin drops, anti-infection and nutrition support were given, and returned to normal about after 3 weeks. There were not found the signs of tumor recurrence and transfer during the follow-up. Conclusion SPTP is a rare low-grade malignant tumor occurring chiefly in young women. The prognosis postoperative is excellent.
出处
《新乡医学院学报》
CAS
2010年第2期193-195,共3页
Journal of Xinxiang Medical University
关键词
胰腺实性假乳头状瘤
胰十二指肠切除术
胰腺肿瘤
solid-pseudopapillary tumor of pancreas
pancreticoduedenectomy
pancreatic tumor
