摘要
目的:探讨Ⅳ期结直肠癌临床病理特征、手术方式与预后的关系,进一步指导临床治疗。方法:对有明确病理诊断的77例Ⅳ期结直肠癌患者临床病理资料及手术方式进行回顾性分析,并予以随访。结果:单因素分析显示:不同术式、肿瘤分化程度、转移范围、术后是否化疗、有无淋巴结转移与患者预后相关(P<0.05)。Cox多因素分析显示:肿瘤转移范围、有无淋巴结转移、术后化疗、不同术式(P<0.05)是影响Ⅳ期结直肠癌患者预后的独立危险因素。联合脏器切除组患者较姑息切除和未切除组患者有较好的术后生存率和生活质量。结论:单器官转移、无淋巴结转移及予积极手术切除联合术后化疗是提示Ⅳ期结直肠癌患者预后较好的独立影响因素。
Objective： To explore the correlation of clinicopathologic charactristics, surgical procedures and prognosis on Stage IV colorectal cancer. Methods： Clinical data of 77 patients with stage Ⅳ colorectal carcinoma undergoing surgical treatment were analyzed retrospectively,all patients were followed-up. Results： By univariate analysis,six variables including operative procedure, tumor differentiation ,distant metastasis,postoperative chemotherapy and lymph node metastasis were related to survival （P〈0.05） ,Cox proportional hazards model study found four independent variables including survival：distant metastasis, lymph node metastasis,postoperative chemotherapy, operative procedure （P〈0.05）. Multi-visceral resection patients had a better postoperative survival rates and life quality than palliative resection and non-resection patients. Conclusion： Only one involved organ, no lymph node metastasis, surgical procedures and postoperative chemotherapy are the independent prognostic factors for overall survival of patients with Ⅳ colorectal cancer.
出处
《天津医科大学学报》
2010年第1期81-83,86,共4页
Journal of Tianjin Medical University
关键词
结直肠癌
化疗
联合脏器切除
预后
影响因素
Colorectal cancer
Chemotherapy
Multi-visceral resection
Prognosis
Influencing factors
