摘要
目的HE染色病理大切片结合免疫组化指标CDX-2研究中低位直肠癌系膜环周切缘癌浸润(CMI)的存在规律,为直肠癌的临床治疗提供病理学依据。方法随机选取2006年11月至2007年7月中低位直肠癌患者41例,手术标本制作成HE染色及CDX-2染色的病理大切片进行检测。结果HE染色及CDX-2染色病理大切片检测中下段直肠癌系膜CMI阳性率分别为21.95%、31.71%。在肿瘤分化程度方面,2种检测方法均证实高、中分化组CMI阳性率低于低分化组(P<0.05)。在肿瘤位置(肿瘤下缘距齿线距离)方面,2种检测方法均显示<5cm组CMI阳性率高于≥5cm组(P<0.05)。患者性别、年龄、肿瘤大体类型、浸润深度、淋巴结转移情况、手术方法(开腹/腹腔镜)均与系膜环周切缘癌浸润阳性率无明显相关性(P>0.05)。结论肿瘤分化程度低、肿瘤位置低是CMI存在的高危因素。对于存在CMI者,术后应行规范的放化疗。
Objective Pathologic large slices by HE staining combined with CDX-2 to study the rules of circumferential margin involvement in middle and （ or ） lower rectal cancer. It proveded a proposal for clinical therapy. Methods We selected 41 patients from November 2006 to July 2007 randomly. The specimens were made into large slices which stained by HE and CDX-2 then detected. Results The positive rate of CMI by HE staining was 21.95% and by CDX-2 staining was 31.71%. Both of the methods were proved that the positive rate of CMI was higher in poorly differentiated than moderately and well-differentiated. Moreover, The positive rate of CMI was lower in the specimens whose lower edge was more than 5cm to the dentate line than less ones. There was no significant correlation betwwen CMI with the fators such as gender, age,pathological general type, tumor infiltration lymphnode metastasis, operation method （ P 〉 0.05 ）. Conclusion There are high risk factors for the prognosis such as low location, poorly differetiated and so on. The patients who have CMI should be treated with normally postoperative radiotherapy and chemotherapy.
出处
《河北医药》
CAS
2010年第4期392-394,共3页
Hebei Medical Journal
基金
河北省普通高校强势特色学科建设基金资助项目(编号:200552)
关键词
直肠癌
环周切缘
环周切缘癌浸润
免疫组化技术
病理大组织切片
rectal cancer
circumferential resection margin
circumferential margin involvement
immunohistoehemistry
pathologic large slice
