期刊文献+

91例儿童人苍白杆菌败血症病原菌及耐药性分析 被引量:9

Identification and Antimicrobial Susceptibilities of Ninety-one Children with Sepsis Caused by Ochrobactrum Anthropi
原文传递
导出
摘要 目的探讨儿童人苍白杆菌败血症的病原学及耐药性特点,为临床的正确诊疗提供依据。方法对从2008年1-11月湖南省儿童医院收治儿童败血症患者中分离的病原体用VITEK2compact进行鉴定和药敏试验,同时对患者临床资料进行分析。结果8264份血标本检出需氧菌876株,检出率10.60%;其中革兰阴性(G-)杆菌542株,检出率61.87%,人苍白杆菌有91株,占革兰阴性(G-)杆菌的16.79%。人苍白杆菌以1~4岁儿童感染率较高。人苍白杆菌对青霉素类和第一、二、三代头孢菌素耐药,对头孢吡肟敏感率高,对亚胺培南、环丙沙星100%敏感。结论人苍白杆菌可引起儿童败血症,耐药率高。头孢吡肟、亚胺培南是人苍白杆菌感染的首选用药。 Objective To study the etiology and drug resistance characteristics of children with sepsis caused by Ochrobactrum anthropi,and to provide the clinical evidence for the correct treatment. Methods Ninety-one strains of Ochrobactrum anthropi were collected from children with sepsis due to Ochrobactrum anthropi in Hunan Children's Hospital from January to November in 2008. All of them were identified with VITEK2compact,drug susceptibility tests were interpreted according to the Clinical and Laboratory Standard Institute (CLSI,2007),and the patients' clinical data were collected to conduct statistical analysis. Results Among 8,264 blood samples,876 strains of aerobic bacteria were detected,with the detection rate of 10.60%; of which 542 strains were gram-negative (G-)bacteria,with the detection rate of 61.87%,91 strains were Ochrobactrum anthropi,accounting for 16.79% of gram-negative (G-) bacteria. 1-to 4-year-old children had a higher infection rate of Ochrobactrum anthropi. Ochrobactrum anthropi was resistant to penicillin and the first-,second-and third-generation cephalosporins,but sensitive to cefepime,imipenem,and ciprofloxacin. Conclusions Ochrobactrum anthropi can cause sepsis in children,and with a higher rate of drug resistance. Cefepime and imipenem are the first choice of medicines for Ochrobactrum anthropi infection.
机构地区 湖南省儿童医院
出处 《实用预防医学》 CAS 2010年第3期447-448,共2页 Practical Preventive Medicine
基金 湖南省科技厅资助课题(2008FJ3193)
关键词 儿童 败血症 人苍白杆菌 耐药 Children Sepsis Ochrobactrum anthropi Drug resistance
  • 相关文献

参考文献5

  • 1Deliere E,VuThien H, Levy V, et al. Epidemiological investigation of Ochrobactrum anthropi strains isolated from a haematology unit[J ]. J Hosp Infect, 2000,44 : 173 - 178.
  • 2杨锡强,易著文.儿科学[M].第6版.北京:人民卫生出版社,2003.208-211.
  • 3NCCLS. Performance standards for antimicrobial susceptibility test [ S]. Ninth informational supplement, NCCLS, 1999.36-75.
  • 4储从家,孔繁林,吴惠玲.83例新生儿血培养阳性结果与临床分析[J].中国感染控制杂志,2007,6(4):253-254. 被引量:13
  • 5周华,凌丽燕,杨青,俞云松,陈亚岗,李兰娟,郑树森.人苍白杆菌耐药性及AmpC酶研究[J].中华检验医学杂志,2005,28(4):378-380. 被引量:22

二级参考文献8

  • 1Coudron PE, Moland ES, Thomson KS. Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center. J Clin Microbiol,2000, 38: 1791-1796.
  • 2Higgins CS, Avison MB, Jamieson L, et al. Characterization, cloning and sequence analysis of the inducible Ochrobactrum anthropi AmpC beta-lactamase. J Antimicrob Chemother, 2001, 47: 745-754.
  • 3Deliere E, Vu Thien H, Levy V, et al. Epidemiological investigation of Ochrobactrum anthropi strains isolated from a haematology unit. J Hosp Infect, 2000, 44:173-178.
  • 4黄华 彭常军.人类苍白杆菌致脑膜炎一例[J].中华医学检验杂志,1999,229:241-241.
  • 5Nadjar D, Labia R, Cerceau C,et al. Molecular characterization of chromosomal class C beta-lactamase and its regulatory gene in Ochrobactrum anthropi. Antimicrob Agents Chemother, 2001,45: 2324-2330.
  • 6Vu-Thien H,Prioreschi S,Sourmay J,et al.Use of the VITAL automated blood culture system in a children's hospital:a one year retrospective study[M].Iunsbruck,Austria:OGHMP,1996:152-155.
  • 7盛夏.人苍白杆菌及其致病作用[J].国外医学(微生物学分册),1999,22(6):23-25. 被引量:6
  • 8王莉,府伟灵,解晓珍,田洪明,张克斌.176次血液培养阳性结果的临床分析[J].中华医院感染学杂志,2003,13(5):489-491. 被引量:12

共引文献40

同被引文献49

引证文献9

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部