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高迁移率族蛋白A2与肿瘤 被引量：4

The high mobility group protein A2 and tumor
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摘要 高迁移率族蛋白A2是一种非组蛋白的染色质相关蛋白,通过与染色质结合后改变其构象,从而激活或抑制转录因子的活性来调节某些基因的转录,进而通过不同的机制导致肿瘤的形成。本文对高迁移率蛋白A2在肿瘤中的作用、导致肿瘤形成的机制及其在肿瘤诊断及预后中的作用作一综述。 The high mobility group A2 （HMGA2）, one of non-histone chromatin proteins, may alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors, and leading to malignant neoplasm formation. This paper focuses on the role of the HMGA proteins in human neoplastic diseases, and discusses the mechanisms by which they contribute to carcinogenesis, and diagnosis strategies based on targeting HMGA proteins.
作者 杨国良 薄隽杰
机构地区 上海交通大学医学院附属仁济医院泌尿外科
出处 《中国癌症杂志》 CAS CSCD 北大核心 2010年第2期156-160,共5页 China Oncology
关键词 HMGA2蛋白 肿瘤 诊断 预后 HMGA2 protein neoplasm diagnosis prognosis
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献30

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二级参考文献17

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共引文献11

同被引文献24

  • 1冯力元,吴佳捷.小干扰RNA抑制HMGB1表达对子宫内膜癌细胞侵袭与迁移的影响[J].中南大学学报（医学版）,2014,39(1):36-42. 被引量：14
  • 2贺荣芳,胡忠良,沈明,文继舫.胃癌组织中PTEN,VEGF,MMP-9的表达及相关性研究[J].中国普通外科杂志,2005,14(3):173-177. 被引量：39
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  • 7Sgarra R, Zammitti $, Lo Sardo A, et al. HMGA molecular network : From transcriptional regulation to chromatin remodeling. Biochim Biophys Ac- ta,2010,1799 : 37-47.
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引证文献4

二级引证文献11

中国癌症杂志
2010年 第2期

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