摘要
目的:研究汞暴露秀丽线虫表型和行为缺陷在后代中的可传递特性。方法:寿命、身体尺寸、身体弯曲频率、头部摆动频率和化学趋向可塑性用于汞急性毒害评价,并进一步分析表型和行为缺陷从汞暴露的当代到后代的可传递特性。结果:汞暴露能够引起包括寿命、身体尺寸、身体弯曲频率、头部摆动频率和化学趋向可塑性等参数在内的多重生物学缺陷,且其毒害与所暴露汞浓度之间密切相关。大部分毒害能够从暴露线虫当代传递给后代。汞暴露对线虫后代寿命的毒害不能够明显恢复。汞暴露线虫后代身体尺寸的缺陷甚至比当代更为严重。此外,高浓度汞暴露通常导致非常纤细的线虫动物出现,且在后代中可观察到更多具有这种表型的线虫。汞暴露导致的线虫身体弯曲和头部摆动频率缺陷在后代中可以大部分或者完全恢复。尽管化学趋向可塑性在汞暴露线虫后代中能够部分恢复,但是化学趋向可塑性仍受到严重的破坏。结论:汞暴露引起的多重生物学毒害可以从暴露当代传递给它们的后代,并且在后代中出现的一些缺陷甚至比当代更为严重。
Objective：To investigate the transferable properties of phenotypic and behavioral defects from mercury（Hg） exposed nematodes Caenorhabditis elegans to their progeny.Method：Endpoints of lifespan,body size,body bend,head thrash,and chemotaxis plasticity were used for the acute toxicity testing.The transferable properties of phenotypic and behavioral defects from exposed parents to their progeny were examined in Hg exposed nematodes.Results：The Hg exposure could cause multi-biological defects of lifespan,body size,body bend,head thrash,and chemotaxis plasticity with a concentration-dependent manner.Most of these toxicities could be transferred to progeny from exposed nematodes.The toxicity on lifespan from Hg exposure could not be obviously recovered in progeny nematodes.The body size defects in progeny of nematodes exposed to Hg appeared even more severe than in their parents.In addition,high concentrations of Hg exposure usually caused the appearance of very slim nematodes,and more nematodes with this phenotype were found in progeny population.The defects of body bends and head thrashes caused by Hg exposure could be largely or completely recovered in progeny nematodes.Moreover,although the chemotaxis plasticity defects in progeny of Hg exposed nematodes could be partially recovered,the chemotaxis plasticity was still seriously impaired.Conclusion：Most of the multi-biological toxicities induced by Hg exposure can be considered to be transferable from parental generations to their progeny,and some specific defects in progeny appeared even more severe than in their parental generations.
出处
《东南大学学报（医学版）》
CAS
2010年第1期1-9,共9页
Journal of Southeast University(Medical Science Edition)
基金
supported by the grants from the National Natural Science Foundation of China(No.30870810)
the Program for New Century Excellent Talents in University
关键词
汞暴露
多重毒性
可传递性
表型
行为
秀丽线虫
mercury exposure
multi-toxicity
transferable property
phenotype
behavior
Caenorhabditis elegans
