摘要
目的:分析黄柏炮制后盐酸小檗碱转化成小檗红碱的情况。方法:采用柱色谱法分离得到小檗红碱,对黄柏不同炮制品中盐酸小檗碱和小檗红碱的含量进行比较。结果:随着炮制温度的升高、时间的延长,制黄柏中部分盐酸小檗碱转化为小檗红碱。温度过高或时间过长时小檗红碱含量降低。结论:黄柏炮制过程控制在40min,温度在180°C时,小檗红碱含量最高。
AIM：To research the chemical modification from berberine hydrochloride to berberrubine in Cortex Phellodendri before and after processing.METHODS：Berberrubine was isolated by column chromatography and the contents of berberine hydrochloride and berberrubine in different processed Cortex Phellodendri were determined by HPLC.RESULTS：With increacing processing temperature and time,part of berberine hydrochloride became berberrubine in processed Cortex Phellodendrin,and berberrubine content decreased under the condition of high temperature operation or overtime processing.CONCLUSION：The experimental data shows that the processed Cortex phellodendri has the maximum average content of berberrubine as processing temperature is maintained as 180 °C for 40 min.
出处
《中成药》
CAS
CSCD
北大核心
2010年第3期443-447,共5页
Chinese Traditional Patent Medicine
基金
"十一五"国家科技支撑计划课题(2006BAI09B06)
关键词
黄柏
炮制
盐酸小檗碱
小檗红碱
HPLC
Cortex Phellodendri
processing
berberine hydrochloride
berberrubine
HPLC
