摘要
本文对１０１名低、无应答儿童采用不同方案加强免疫，进行随机对照前瞻性研究观察，表明，对母亲ＨＢｓＡｇ阳性的低、无应答婴幼儿采用注射分枝杆菌多糖与乙肝疫苗（３０μｇ×３）联合应用，免后１年抗体阳转率可达９０％左右；对母亲ＨＢｓＡｇ阴性的低、无应答婴幼儿采用加强１支１０μｇ乙肝疫苗，可使近一半婴幼儿产生抗－ＨＢｓ。利用ＰＣＲ检测低、无应答者的ＨＢＶ－ＤＮＡ，仅有３８５％为ＨＢＶ感染者，母亲为ＨＢｓＡｇ阳性者的无应答婴幼儿若不进行加强免疫，仍存在着ＨＢＶ感染的危险性。
In order to explore the best boaster strategy for children with low-and non-response to HBV vaccine, a randomized controlled trial for evaluation of simple HBV vaccine (30μg×3) and HBV vaccine (30μg×3) combined with Mycobacteria Phlei Polysaccharides (MPS, MPS-A 20μg/ml×15, MPS-B 2μg/ml×15) was conducted in 59 infants of HBsAg positive mothers. The infants with low-and non-response were tested for HBV-DNA using PCR, only 3.8% were infected with HBV, most of the infants were free of HBV infecion. Therefore, the booster vaccination with the HB vaccine and MPS was necessary, especially for children of HBsAg positive mothers.
出处
《疾病监测》
CAS
1998年第12期447-450,共4页
Disease Surveillance
