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UPA、Survivin在乳腺癌组织中的表达及临床意义 被引量:2

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摘要 目的探讨尿激酶型纤溶酶原激活剂(UPA)和生存素(Survivin)在乳腺良、恶性肿瘤组织中的表达及临床意义。方法采用PV免疫组化法,检测77例乳腺癌和22例乳腺腺瘤患者病灶切除标本中的Survivin、UPA表达;分析两者表达与临床病理参数的关系。结果在腺瘤和腺癌中,Survivin阳性率分别为72.72%、70.13%,两者比较无统计学差异(P>0.05);UPA阳性率分别为31.28%、58.44%,腺癌阳性率明显高于腺瘤(P<0.01)。腺癌临床分期高、浸润性癌和有淋巴结转移者Survivin、UPA阳性率高(P均<0.05)。结论乳腺癌患者Survivin、UPA表达率较高,两者呈低度正相关,其表达与临床病理参数有关;检测两者对乳腺癌的靶向治疗和预后判断有指导意义。
出处 《山东医药》 CAS 北大核心 2010年第5期73-74,共2页 Shandong Medical Journal
基金 张家口市科技局科研项目(061158)
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