摘要
人体免疫系统可以通过杀伤受感染的细胞的方式保护不受侵入的病原体与微生物的侵害,而只对正常组织造成最小程度的损害。为了维持这种平衡,CD4+CD25+调节性T细胞在控制免疫应答与维持外周免疫耐受中起重要作用。这种T细胞的数量减少或功能的缺失可能导致自身免疫疾病的发生。增强调节性T细胞免疫抑制功能的治疗措施已经被证明可以改善自身免疫性疾病的病情,本文就调节性T细胞的作用机制及与常见自身免疫性疾病的关系做一综述。
The main function of human immune system is to protect us from invading pathogens and microorganisms by destroying infec- ted cells, while minimizing collateral damage to tissues. In order to maintain this balance, various immune effector cells are indispensable. Within the large pool of different immune effeetor cells ,the CD4＋ CD25＋regulatory T cells play an important role in controlling immune responses and the maintenance of peripheral immune tolerance. The decrease or afunction of them will result in the development of autoimmune disease. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve the course of autoimmune diseases. The relationship between the function of regulatory T cells and common autoimmune disease will be reviewed in this article.
出处
《安徽医药》
CAS
2010年第3期249-252,共4页
Anhui Medical and Pharmaceutical Journal
基金
国家自然科学基金(No30771849
30972530)
2008年科技厅年度科研计划资助基金(No08020303070)
安徽医科大学博士启动基金(No01XJ2006001)
安徽省自然科学基金(No090413133)
