摘要
目的:观察复方丹参滴丸应用于重度子痫前期合并毛细血管渗漏综合征(capillary leak syndrome,CLS)的临床疗效。方法:将2008年1月-2009年12月期间本院产科ICU收治的84例重度子痫前期产后合并毛细血管渗漏综合征的产妇随机分为A组(硫酸镁+复方丹参滴丸)40例和B组(硫酸镁)组44例。比较两组反映毛细血管渗漏程度的临床指标,如产后5天内24h尿蛋白排出总量、吸氧小时数、产后第6天胸腹水消失情况及血浆白蛋白水平。结果:(1)产后5天内尿蛋白排出总量A组(17.57±1.64)g明显低于B组(19.39±1.63)g,差异具有统计学意义(P<0.05);(2)产后吸氧小时数A组(19.76±2.68)小时明显少于B组(22.83±2.92)小时,差异具有统计学意义(P<0.05)。(3)出院时胸腹水阴性率A组(57.5%)(23/44)明显高于B组(25.0%)(11/44),差异具有统计学意义(P<0.05)。(4)出院时血浆白蛋白水平(25.85±2.10)g/L和(23.50±1.87)g/L,差异具有统计学意义(P<0.05)结论:复方丹参滴丸对重度子痫前期的毛细血管渗漏综合症有明显的治疗效果。
Objective：The aim of this study was to assess the clinical results of treatment of capillary leak syndrome with severe preeclampsia with compound Danshen Dropping Pills. Methods：84 cases of postpartum patients with severe preeclampsia with capillary leak syndrome in the past 2 years （from January,2008 to December,2009） were randomly divided into group A （40cases）and group B（44 cases）. The group A was treated with compound Danshen Dropping Pills and magnesium sulfate.The group B was treated with magnesium sulfate. We compared the clinical indicators of the two groups which could reflect the severity of capillary leak syndrome,such as postpartum urinary protein discharged within 5 days,postpartum oxygen inhalation hours within 5 days,the negative rates of pleural effusion and peritoneal fluid at the sixth day after childbirth,the serum albumin level at the sixth day after childbirth.Results：（1） The total urinary protein discharged within 5 days after childbirth of group A （17.57±1.64）g was significantly lower than that of B group （19.39±1.63） g with a statistically significant difference （P0.05）.（2） The number of oxygen inhalation hours within 5 days after childbirth of group A （19.76±2.68） hours was significantly shorter than that of group B（22.83±2.92）hours with a statistically significant difference （P0.05）.（3） The negative rate of pleural effusion and peritoneal fluid at the sixth day after childbirth of group A （57.5%） was significantly higher than that of group B （25.0%） with a statistically significant difference （P0.05）. （4） The serum albumin level at the sixth day after childbirth of group A（25.85±2.10）g/L was significantly higher than that of group B （23.50±1.87）g/L with a statistically significant difference （P0.05）. Conclusion：Compound Danshen Dropping Pills has obvious therapeutic effect on severe preeclampsia with capillary leak syndrome.
出处
《中华中医药学刊》
CAS
2010年第3期665-667,共3页
Chinese Archives of Traditional Chinese Medicine
