摘要
目的观察普岁帕酮与洋地黄转复慢性心房颤动的作用。方法将心房颤动发作时间大于3周的患者随机分为普岁帕酮组和洋地黄组,普岁帕酮组先静脉推注2 mg/kg,再以5 mg/kg维持24 h,后改口服每天450 mg治疗4周。洋地黄组先静脉推注毛花甙C 0.4 mg,然后每6 h静脉推注0.2 mg,24 h后改口服地高辛每日0.25 mg。结果普罗帕酮组17例(48.6%)转复为窦性心律,洋地黄组仅2例转复成功。普罗帕酮组转复成功者与未转复者相比,左房内径明显较小(P<0.001),心房颤动持续时间显著较短(P<0.001)。结论普罗帕酮可有效地转复慢性心房颤动,洋地黄转复慢性心房颤动疗效不佳;左房内径、心房颤动持续时间是影响转复成功的重要因素。
Objective To study the results between prupafenone and digitalis for conversion of cilronic atrial fibrillation. Methods Patients with an atrial fibrillation, who continued more than 3 weeks, were randomly divided intn propafenone group and digitalis group. In propafenone group the patients were given propafenone 2 mg/kg intravenously first, at heginning, and 5 mg/kg continued 24 hours, then 450 rag/day, oral administration, for 4 weeks. Patients in digitalis group began with lanatoside C 0.4 mg intravenously, fullowed every 6 hours and were given 0.2 mg until 24 hours, then digoxir, 0. 25 mg every day, for 4 weeks. Results 17（48.6% ） patients in propafenone group, chronic atrial fibrillation were transferred to sinus rhythm; In digitalis group, only two eases were transferred to sinus rhythm successfully. In propafenone group, the left. atrial diameter of winners were smaller than the non -diversion patients（ P 〈 0. 001 ） , and the duration of atrial fibrillation nf winners were shorter than Ihe non - diversion patients（ P 〈 0. 001 ）. Conclusion Propafenone is a effective drug in re - turn with chronic atrial fibrillation, the efficacy of digitalis was unsatisfactory. The left atrial diameter and the duration of atrial fibrillation were important taetors about chronic atrial fibrillation were transferred to sinus rhythm successfully.
出处
《中国医学创新》
CAS
2010年第9期21-22,共2页
Medical Innovation of China
关键词
心房颤动
普罗帕酮
洋地黄
Atrial fibrillation
Propafenone
Digitalis
