期刊文献+

三烯生育酚生物学功能及合成调控研究进展 被引量:2

Advances in biological functions and biosynthesis regulation of tocotrienols
下载PDF
导出
摘要 介绍了三烯生育酚的生物合成途径,重点综述了三烯生育酚在神经保护、抗癌、降低胆固醇以及抗氧化等方面的优越生物学功能,以及利用关键酶的高效表达和前体物质水平的提高等植物代谢工程手段提高植物体内三烯生育酚生物合成水平的研究进展。 The molecular and the biosynthetic pathway of tocotrienol were briefly introduced. And the powerful neuroprotective,anti-cancer,cholesterol lowering and antioxidation properties of tocotrienols as well as the strategies of metabolic engineering used in elevating biosynthesis level of the tocotrienols in plants were mainly reviwed.
出处 《广西植物》 CAS CSCD 北大核心 2010年第1期122-126,59,共6页 Guihaia
基金 广东省科技攻关项目(粤科计字[2006]621号)~~
关键词 三烯生育酚 生物合成 神经保护 抗癌 植物代谢工程 tocotrienol biosynthesis neuroprotection anticancer function plant metabolic engineering
  • 相关文献

参考文献40

  • 1Adachi H,Ishii N.2000.Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans[J].Biological Sci Med Sci,55:280-285.
  • 2Adul Mutalib MS,Khaza'aia H,Klaus W,et al.2003.Palm-tocotrienol rich fraction(TRF)is a more effective inhibitor of LDL oxidation and endothelial cell lipid peroxidation than a-tocopherol in vitro[J].Food Res International,36:405-413.
  • 3Ahn KS,Sethi G,Krishnan K,et al.2007.γ-Tocotrienol inhibits nuclear factor--κB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of Antiapoptotic gene products and potentiation of apoptosis[J].Biol Chem,282(1):809-820.
  • 4Becker EM,Nissen LR,Skibsted LH.2004.Antioxidant evaluation protocols:food quality or health effects[J].European Food Res Tech,219:561-571.
  • 5Black TM.,Wang P,Maeda N,et al.2000.Palm tocotrienols protect ApoE+/-mice from diet-induced atheroma formation[J].Nutr130:2 420-2 426.
  • 6Brigelius-Flohe R,Trabet MG.1999.Vitamin E:function and metabolism[J].J Federation of Amer Societies Exper Biol,13:1 145-1 155.
  • 7Cahoon EB,Hall SE,Ripp KG,et al.2003.Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content[J].Nat Biotechnol,21:1 082-1 087.
  • 8Cicero AF,Gaddi A.2001.Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions[J].Phytother Res,15:277-289.
  • 9Collakova E,DellaPenna D.2003.Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis[J].Plant Physiol,131:632-642.
  • 10Collakova E,DellaPenna D.2001.Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp.PCC 6803 and Arabidopsis[J].Plant Physiol,127:1 113-1 124.

二级参考文献46

共引文献17

同被引文献18

  • 1Sylvester PW,Shah SJ.Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells[J].Front Biosci,2005,10(3):699-709.
  • 2Sen CK,Khanna S,Roy S.Tocotrienols in health and disease:the other half of the natural vitamin E family[J].Mol Aspects Med,2007,28(5):692-728.
  • 3Husain K,Francois RA,Hutchinson SZ,et al.Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration[J].Pharmacology,2009,83(3):157-163.
  • 4Wada S,Satomi Y,Murakoshi M,et a1.Tumor suppressive effects of tocotrienol in vivo and in vitro[J].Cancer Letters,2005,229(2):181-191.
  • 5Srivastava JK,Gupta S.Toeotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells[J].Biochem Biophys Res Commun,2006,346(2):447-453.
  • 6Constantinou C,Papas A,Constantinou AI.Vitamin E and cancer:An insight into the anticancer activities of vitamin E isomers and analogs[J].Int J Cancer,2008,123(4):739-752.
  • 7Comitato R,Nesaretnam K,Leoni G,et al.A novel mechanism of natural vitamin E tocotrienol activity:involvement of ERbeta signal transduction[J].Am J Physiol Endocrinol Metab,2009,297(2):427-437.
  • 8Sakai M,Okabe M,Tachibana H,et a1.Apoptosis induction byδ-tocotrienol in human hepatoma Hep3B cells[J].J Nutr Biochem,2006,17(10):672-676.
  • 9赵堪必,杨陪增.跟科学[M].第7版.北京:人民卫生出版社,2008:145-146.
  • 10Fernandes NV, Guntipalli PK, Mo H. D-5-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells [ J ]. Anticancev Res,2010,30 ( 12 ) :4937-4944.

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部