摘要
目的探讨人工肝血浆置换治疗重型肝炎的临床疗效、时机及安全性。方法选择2006年9月-2009年12月在简阳市人民医院感染科住院的重型肝炎165例,分为治疗组(内科药物治疗加血浆置换,n=89例),以及对照组(单纯内科治疗,n=76例),比较两组在治疗4周时的疗效。结果治疗组血浆置换治疗后患者症状、精神、食欲、体力均有明显改善,血浆置换治疗结束时即刻TBIL、ALT、AST、PTA均明显好转(P<0.01)。治疗4周时,治疗组总有效率明显高于对照组(P<0.01),其中早期、中期重型肝炎的治疗有效率分别为85.71%,71.87%,显著高于对照组的63.16%,53.85%(P均<0.01)。血浆置换治疗未发现严重不良反应。结论应用血浆置换治疗重型肝炎是目前较为成熟的肝脏替代疗法,具有一定疗效,且早、中期的疗效较晚期好。
Objective To study the clinical efficacy,timing and safety of plasma exchange treatment on severe hepatitis.Methods From September 2006 to December 2009,165 cases with severe hepatitis were selected,who were hospitalized in the department of infectious diseases,Jianyang city people＇s hospital.The patients were divided into treatment group （medical therapy plus plasma exchange,n=89 cases）,as well as the control group （medical therapy alone,n=76 cases）.After 4 weeks,The treatment efficacy were compared.Results After plasma exchange treatment,the symptoms,spirit,appetite,physical strength of patients were significantly improved.Compared with pretreatment,The serum TBIL,ALT,AST,PTA levels were significantly improved at the end of plasma exchange treatment （P 〈0.01）.After treatment for 4 weeks,the total effective rate of treatment group was significantly higher than control group（P 〈0.01）.The effective rate of the early stage,medium stage of severe hepatitis （85.71%,71.87%） in treatment group,were higher than the control group （63.16%,53.85%）,respectively.The two groups were significantly different （P 〈0.01）.Severe adverse reactions were not found in plasma exchange treatment.Conclusions The plasma exchange treatment of severe hepatitis has a certain effect.The clinical efficacy of plasma exchange using in early and middle stage of severe hepatitis is better than using in the late stage.
出处
《北京医学》
CAS
2010年第3期197-199,共3页
Beijing Medical Journal
关键词
重型肝炎
血浆置换
治疗
评价
Severe hepatitis Plasma exchange Therapy Analysis
