摘要
为了提高膀胱癌的治疗效果，采用ＢＣＧＣＷＳ（细胞壁骨架）行膀胱内灌注，防治浅表膀胱癌复发。５３例膀胱癌患者手术后分为ＢＣＧＣＷＳ组和ＢＣＧ组。ＢＣＧＣＷＳ组（２５例）５ｍｇＢＣＧＣＷＳ加无菌生理盐水５０ｍｌ注入膀胱，ＢＣＧ组（２８例）７５ｍｇＢＣＧ加生理盐水５０ｍｌ注入膀胱。每周１次，连续６周，以后每月一次连续两年。随访６～３２个月，中位数２６个月。两组比较肿瘤复发率无显著性差异，ＢＣＧＣＷＳ组毒副反应比ＢＣＧ组明显减少。结论：ＢＣＧＣＷＳ能有效地防治浅表膀胱癌复发，毒副反应低，并具有保存期长，使用方便的特点。
BCG CWS has been used in clinical study for preventing the recurrence of superficial transitional cell carcinoma.53 patients were randomized into two groups:BCG CWS group and BCG group.The protocol of immunoprophylaxis included 6 weekly instillation of 5mg BCG CWS in 50ml normal saline via a catheter.Immunotherapy was given once monthly for at least two years.Results:Followup (from 6 to 32 months with a median 26.3 months) consisted of cystoscopy and cytology with cold cup biopsies carried out every 3 months for 2 years.It showed that in three patients (12.0%) recurrence occumed after the instillation of BCG CWS.During the instillation the rate of toxic side effects was very low.The intravesical BCG CWS appears to be an effective prophylaxis against recurrence.It is supperior to BCG vaccine with fewer complication,but with similar effective rate ( P >0.05).Long term result needs further investigation.BCG CWS can be preserved even longer without changing its antitumor property and is easily available for rural hospitals.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1998年第12期721-723,共3页
Chinese Journal of Urology
基金
卫生部科学研究课题基金
