摘要
目的探讨全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)患者血清白细胞DR抗原(HLA-DR)动态变化。方法226例患者按SIRS诊断标准分为SIRS组(156例)和非SIRS组(70例);SIRS组按预后分为生存组(74例)和死亡组(82例);另选60例健康成人作为正常对照组。流式细胞仪测定单核细胞中HLA-DR表达强度。结果SIRS组、死亡组患者血清中单核细胞HLA-DR的表达强度随着时间推移和病情加重均不断降低,尤其是HLA-DR最终低于非SIRS组和生存组(P<0.01)。HLA-DR与急性生理学和慢性健康状况评分Ⅱ(APACHEⅡ)有显著相关性。结论SIRS患者单核细胞HLA-DR表达强度持续降低提示预后不良,检测对早期诊治、判断病情及预后有重要意义。
Objective： To explore the dynamic changes of HLA-DR in serum levels in patients with systemic inflammatory response syndrome.Methods：226 cases were divided into two groups according to diagnostic criteria of SIRS： SIRS group（n= 156） and non SIRS group（n= 70）.SIRS group was divided into two subgroups according to the prognosis： survival group（n= 74） and death group（n= 82）.Another 60 healthy adults were served as normal controls.Human leukocyte antigen DR（HLA-DR）expression intensity of monocytes were measured by flow cytometry.Results：HLA-DR expression intensity of monocytes in SIRS and death groups declined progressively,especially the value of HLA-DR was lower compared with that of non SIRS and survival group（P0.01）.There was significant correlation among HLA-DR and APACHEⅡ.Conclusion：The progressive declination of HLA-DR expression intensity of monocytes in patients with SIRS indicates a poor prognosis and the related detection is of significance to the early diagnosis,treatment and prognosis.
出处
《泰山医学院学报》
CAS
2010年第1期20-22,共3页
Journal of Taishan Medical College
