摘要
目的分析某医院抗菌药物使用情况,为合理使用抗菌药物提供参考依据。方法回顾性收集该院2004～2008年抗菌药物使用记录,采用Excel2003进行统计;以限定日剂量(DDD)为单位,计算抗菌药物使用强度(AUD)并进行分析。结果该院AUD 5年间波动较大;三代头孢、青霉素类+酶抑制剂和二代头孢排名AUD前3位;排名AUD前10位的药品均来自于头孢菌素类、青霉素类+酶抑制剂、硝咪唑类和喹诺酮类,绝大多数都是注射剂;国内外医院的比较显示,该院AUD显著低于我国平均水平,与韩国和美国用药存在较大差异。结论该院可能存在用药过度、用药集中、广谱抗菌药物的使用率高等问题;应严格限制头孢菌素类、青霉素类+酶抑制剂和喹诺酮类的临床应用,避免AUD的过快增长。
OBJECTIVE To provide an evidence for rational use of antibacterials in the clinic through analysis of the antibacterial use in a hospital.METHODS By retrospective study,the data of drug used from 2004 to 2008 were collected and analyzed by Excel 2003.Taking defined daily dose（DDD） as the unit,antibacterial use density（AUD） was calculated and carried on the analysis.RESULTS The AUD was fluctuant during the last 5 years.The third generation cephalosporins,penicillin/beta-lactamase inhibitors and the second generation cephalosporins ranked in the first three places in turn.The drug ranking in the first ten places came from cephalosporins,penicillin/beta-lactamase inhibitors,nitromidazoles,and fluoroquinolones and the majority of antibacterials were injection.Comparing with the domestic and foreign hospital,AUD in the hospital was significantly lower than the average level of China＇s.The use of antibacterials was different from South Korea and America.CONCLUSIONS The hospital may exist such problems as overmedication,dense medication and the high use ratio of broad-spectrum antimicrobial agents.Cephalosporins,penicillin/beta-lactamase inhibitors and fluoroquinolones should be strictly limited in the clinic to avoid an excessive increase in AUD.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第6期848-851,共4页
Chinese Journal of Nosocomiology
关键词
抗菌药物
限定日剂量
使用强度
用药分析
Antibacterials
Defined daily dose
Antibacterial use density
Drug analysis
