摘要
目的探讨酚磺乙胺对干、湿化学酶法测定血清肌酐结果的影响。方法参照干扰试验的方法,用干、湿化学酶法测定实验组与对照组血清肌酐结果并进行统计学分析。结果当血中酚磺乙胺浓度>9.38mg/L时,干、湿化学酶法比真实结果低:当酚磺乙胺浓度为300.00mg/L时,真实肌酐浓度为66.90μmol/L,干化学测定肌酐结果为40.78μmol/L,湿化学为17.35μmol/L,随着血中酚磺乙胺浓度的升高,测定结果低于真实结果的程度越大;且在相同药物浓度下,酚磺乙胺对湿化学肌酐测定结果的影响远远大于干化学。结论血中酚磺乙胺>9.38mg/L时,会明显影响干、湿化学酶法测定血清肌酐的结果。因此,血中酚磺乙胺浓度<9.38mg/L时测定血清肌酐,结果才可信。
Objective To study the effect of ethamsylate on serum creatinine by dry and wet chemistry assay. Methods Serum creatinine levels in experimental and control groups were measured by referring to the interference test and statistically analyzed. Results When the serum ethamsylate concentration was above 9.38mg/L, the serum creatinine level measured by dry and wet chemistry was lower than its real level, and was much lower measured by wet chemistry than by dry chemistry. When the concentration of ethamsylate was 300.00mg/L, the real serum creatinine level was 66.90μmol/L. The serum creatinine level was 40.78μmol/L and 17.35μmol/L measured by dry and wet chemistry, respectively. The higher the ethamsylate concentration was, the lower the creatinine level was. Furthermore, the effect of ethamsylate on creatinine by wet chemistry assay was much stronger than that by dry chemistry assay. Conclusion When the serum concentration of ethamsylate reaches 9.38mg/L, ethamsylate exerts its effect on creatinine by dry and wet chemistry assay, indicating that the serum creatinine level should be measured when the serum concentration of ethamsylate is lower than 9.38mg/L.
出处
《军医进修学院学报》
CAS
2010年第3期249-250,共2页
Academic Journal of Pla Postgraduate Medical School
关键词
肌酸酐
酶法
酚磺乙胺
干化学
湿化学
Creatinine
Enzyme Method
Ethamsylate
Dry Chemistry
Wet Chemistry
