摘要
目的 探讨CD44粘附分子表达与肿瘤转移相关性的意义.方法 采用LSAB免疫组化法对淋巴结转移性腺癌31例,鳞癌27例,和伴有淋巴结转移的鼻咽癌20例,食管鳞癌39例的原发癌石蜡切片进行CD44单抗染色,观察其表达阳性率及反应强度.结果1.淋巴结转移性腺癌CD44阳性表达18例(57%),转移性鳞癌阳性表达7例(2%),两组间腺癌阳性表达率明显高于鳞癌(P<O.05).但其中肺鳞癌肺门淋巴结转移高于腺癌.两组间阳性表达强度无明显差异(P>0.05).2.伴有淋巴结转移的鼻咽癌阳性表达11例,占55%(11/20),食管鳞癌阳性表达25例,(64%).两组间阳性表达率无明显差异(P>0.05),且阳性反应强度亦无显著的差异(P>0.05).结论 在多数肿瘤CD44表达与肿瘤转移密切相关,而以CD44V为明显,但无一致性.因此CD44不能作为肿瘤转移通用性标记物.
PURPOSE This paper studied the significance of the relationship between expression of CD44 adhesion molecules and tumor metastasis. METHODS The CD44 expression in metastatic adenocarcinomas 31 cases. Squa-mous-cell carcinomas 27 cases in nodes and primary nasopharyngeal carcinomas 39 cases with nodal metastasis were used. LSAB immunohistochemical staining of CD44 monoclonal antibody. RESULTS 1. The CD44 expression was found in nodal metastatic adenocarcinomas 18 cases (57%) and squamous-cell carcinomas 7 cases (26%). There was a notable difference between two groups of CD44 expression. But the lung squamous-cell carcinoma showed nodal metastasis in lung hilum higher than the adenocarcinoma. 2. The CD44 expression was present in primary nasopharyngeal carcinomas 11 cases (55%) and esophageal squamous-cell carcinomas 25 cases (64%) with nodal metastasis. There was no significant difference between the two groups. Based on our results and new references suggest that these is a close relationship between the CD44 expression and tumor meatstasis in numerous tumors. But these were not constant. CONCLUSION Therefore the CD44 expression can not be used as a univeral indicator in tumor metastasis.
出处
《中国癌症杂志》
CAS
CSCD
1998年第4期267-270,共4页
China Oncology
关键词
CD44
表达
肿瘤转移
CD44 Expression Tumor Metastasis.
