摘要
目的:观察雷贝拉唑三联疗法对幽门螺杆菌(HP)阳性的消化性溃疡的疗效。方法:70例符合条件的患者随机分为两组,治疗组35例,应用雷贝拉唑+甲硝唑+克拉霉素三联1周,之后雷贝拉唑3周疗法;对照组35例,应用奥美拉唑+甲硝唑+克拉霉素三联1周,之后奥美拉唑3周疗法。治疗前、治疗4周后均进行胃镜和HP检查,评价疗效。结果:治疗组与对照组溃疡愈合率分别为97.06%和93.75%,两组间差异无统计学意义(P>0.05);HP根除率分别为91.18%和68.75%,两组间差异有统计学意义(P<0.05)。结论:雷贝拉唑三联疗法可作为HP感染的消化性溃疡的首选疗法。
Objective：To investigate the treatment effect of trigeminy with rabeprazole on peptic ulcer with Helicobacter pylori in- fection.Methods：Seventy eligible patients were randomly assigned to 2 groups （n=35）：rabeprazole, metronidazole and clarithromycin were administered in the rabeprazole group for 1 week, followed by rabeprazole for 3 weeks.In the control group, omeprazole,metronidazole and clarithromycin were administered for 1 week, followed by omeprazole for 3 weeks.Gastroscope and Helicobacter pylori detection were carried out pretreatment and post-treatment at 4 weeks to test the treatment effect.Results：The healing rate of ulcer were 97.06% and 93.75% in the rabeprazole group and control group respectively without statistical difference （P〉0.05）.The eradication rates of Helicobacter pylori were 91.18% and 68.75% with statistical difference （P〈0.05）.Conclusion：Trigeminy with rabeprazole is the optimal choice for peptic ulcer.
出处
《现代医药卫生》
2010年第8期1134-1135,共2页
Journal of Modern Medicine & Health
