摘要
肾小球系膜增生是多种肾脏疾病的基本病理过程，系膜增生性肾小球肾炎（MsPGN）是常见的病理类型。目前MsPGN发病机制仍不清楚，近年来以fractalkine、白细胞介素、转化生长因子-β等为代表的细胞因子逐渐成为MsPGN发病机制的研究热点，多种细胞因子在MsPGN发生发展中起重要作用。目前在MsPGN治疗上也取得一定的进展，对吗替麦考酚酯有了更深的认识，其在难治性肾病综合征患儿的治疗中取得了良好效果。
Mesangial proliferation is a basic pathologic process of many kidney diseases, mesangial proliferative glomenalonephritis（MsPGN） is the common pathological type. The pathogenesis of MsPGN still remains unclear. Recently, cytokines of fractalkine,intedeukin and TGF-[3 gradually become hotspot in the pathogenesis of MsPGN. Studies shows that a variety of cytokines play an important roles in the development of MsPGN and the mechanism has been gradually clarified. Certain progress has been made in treatment,and more profound understanding of mycophenolate mofetil has been received, the treatment of the MsPGN as manifestations with refractory nephrotic syndrome has been achieved good effect. This review is based on the recent years of the primary non-IgA MsPGN progress.
出处
《国际儿科学杂志》
2010年第2期179-182,共4页
International Journal of Pediatrics
关键词
系膜增生性肾小球肾炎
发病机制
治疗
Mesangial proliferative glomerulonephritis
Pathogenesy
Management
