摘要
目的:研究甲状腺机能亢进症(简称甲亢)患者经抗甲状腺药物治疗后骨密度的改善情况。方法:用单能X线骨吸收仪(SXA)测量48例绝经前妇女和50岁以前男性甲亢患者及19例健康人群的骨密度,同时测定甲亢患者的血清甲状腺功能,自甲亢诊断和治疗开始分为3组,即A组:≤3个月,B组:3～12个月,C组:>12个月,对治疗后不同阶段的骨密度进行评估,并与健康人群进行比较。结果:B组骨密度(-1.41±0.25)较A组(-2.02±0.74)无明显改善(P>0.05),C组骨密度(-0.14±0.74)较A、B两组明显升高(均P<0.01),且与健康对照组(-0.12±0.68)比较差异无显著性(P>0.05)。不同阶段TSH,FT3,FT4与骨密度没有相关性。结论:甲亢患者的骨量减少或者骨质疏松经抗甲状腺药物治疗后具有一定的可逆性。
Objective：To investigate the improvement of bone mineral density in 48 hyper-thyroid patients after antithyroid drug therapy.Methods：The bone mineral density of 48 young hyperthyroid patients and 19 healthy subjects was measured by SXA,and meantime serum thyroid function was measured by immunochemiluminescent.The patients was divided into three groups according to the interval of the time elapsed between the initial diagnosis of the hyperthyroidism and the measurement of SXA were recorded：group A：≤3 months,group B：3-12 months,group C：12 months,and then the bone mineral density of the different stage was evaluated.Results：The bone mineral density of group B（-1.41±0.25） was not different from that of group A（-2.02±0.74）,which was signifinant in group C（-0.14±0.74）,and there was no differences between C and the control group（-0.12±0.68.） Conclusion：The decrease of the bone mineral density in hyperthy-roid patients has definite reversibility after antithyroid drug therapy.
出处
《温州医学院学报》
CAS
2010年第1期46-48,共3页
Journal of Wenzhou Medical College
