摘要
目的研究测定结直肠癌患者全身热疗术前后血浆前列腺素E2（PGE2）水平及细胞免疫功能变化及其临床意义。方法2002年6月至2006年12月收治的结肠癌患者24例，男13例，女11例，年龄14-73岁，平均（56．3±17．1）岁，对照组为24名健康体检者。用PGE2酶免药盒分别测定患者手术前后的外周血PGE2水平及细胞免疫T细胞亚群变化。结果结直肠癌患者外周血PGE2经全身热疗治疗后明显降低，细胞免疫功能明显提高，P值有显著性差异。结论外周血PGE2围手术期下降水平与细胞免疫功能的提高呈明显相关性，全身热疗在杀灭癌细胞同时提高机体免疫力。外周血PGE2作为结直肠癌患者全身热疗治疗判断疗效的一项辅助性监测指标有较好的应用前景。
Objective To study the clinical significance of periphenal blood PGE2 and cellular immune function assay in patients with colonectal cancer. Methods From June, 2002 to December, 2007, 24 patients with colonrectal cancer were accepted in the department of oncology in Shanghai Jing＇ an centre hospital. 13 were male an 11 were female,the average age was （56.3± 17.1） years. In the study, 24 people found health at physical examination were considered as controls. According to Dukes classification, the pathologic diagnoses place 8 patients at stage C and 16 patients at stage D. The levels of peripheral blood PGE2 and cellular immune function pre- and post- operation were assayed by PGE2.EIA system. Results The patients with colonrectal cancer had a high concentration of peripheral blood PGE2.These levels were considerably higher than the normal in this study. When the levels of peripheral blood PGE2 and cellular immune function were assaye 10 days after the operation, they had significant change. Conclusions The levels of peripheral blood PGF~ may be considered as an auxiliary monitor marker of efficacy judgment.
出处
《中国医药指南》
2010年第10期26-28,共3页
Guide of China Medicine
