摘要
目的探讨经门静脉外周血干细胞移植(VPBSCT)治疗肝硬化失代偿期的疗效。方法选择37例肝硬化失代偿期患者,采取经门静脉途径肝内移植自体外周血干细胞,观察患者移植术前、术后2个月的肝功能〔包括血清丙氨酸氨基转移酶(ALT)、总胆红素(TB)、清蛋白(ALB)水平及凝血酶原时间(PT)〕变化及临床症状改善情况。结果移植术后2个月患者血清ALT、TB水平及PT与术前比较,差异有统计学意义(P<0.05);移植术后3个月患者血清ALT、TB、ALB水平及PT与术前比较,差异亦有统计学意义(P<0.05)。移植术后2个月,腹腔积液减轻17例(70.8%,17/24),乏力好转26例(83.9%,26/31),食欲改善28例(75.7%,28/37),体力好转25例(67.6%,25/37),腹胀减轻21例(63.6%,21/33)。除5例患者移植术后腹腔积液加重,1例因上消化道大出血死亡外,未发现其他明显不良反应及并发症。结论VPBSCT治疗肝硬化失代偿期具有疗效好、费用低及技术风险少的优势。
Objective To evaluate the effect of vein peripheral blood stem cell transplantation （VPBSCT） on decompensated cirrhosis.Methods Thirty-seven decompensated cirrhosis patients received VPBSCT.Liver function including serum alanine aminotransferase （ALT）,and the levels of total bilirubin （TB）,albumin （ALB）,and prothrombin time （PT） changes,clinical symptom improvement were observed before VPBSCT and 3 months after.Results There was significant difference in serum ALT,TB levels and PT between pre-treatment and 2 months after VPBSCT （P〈0.05）,and between pre-treatment and 3 months after VPBSCT （P〈0.05）.The postoperative ascites increased in 5 patients,1 died of upper gastrointestinal bleeding.Ascites decreased in 17 patients （70.8%,17/24）,fatigue improved in 26（83.9%,26/31）,appetite improved in 28（75.7%,28/37）,body force improved in 25 （72.9%,25/37）,abdominal distension reduced in 21（63.6%,21/33）.No patients presented with obvious adverse reactions or complications except that 1 with slight bone pain.Conclusion VPBSCT has good efficacy with low cost and fewer technological risks.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第8期852-854,共3页
Chinese General Practice
关键词
外周血干细胞移植
肝硬化
门静脉
治疗结果
Peripheral blood stem cells transplantation
Liver cirrhosis
Portal vein
Treatment outcome
