摘要
目的：研究乳腺良恶性病变细胞形态与ＤＮＡ含量。方法：利用传统的Ｆｅｕｌｇｅｎ染色及计算机图像分析系统软件检测细胞形态及ＤＮＡ含量。结果：ａ．乳腺良恶性病变之间、乳腺癌Ⅰ级与Ⅱ级、Ⅲ级之间、淋巴转移组与非转移组之间ＮＡ、ＣＡ、Ｎ／Ｐ及Ｐｎ有显著差别（Ｐ＜００１）；ｂ．乳腺良恶性病变之间ＤＮＡ含量存在显著差别Ｐ＜００１；ｃ．综合细胞形态及ＤＮＡ含量参数经逐步判别分析建立综合判别式，良性病变回代率为１００％，恶性肿瘤回代率９８７５％。结论：Ｎ／Ｐ，ＮＡ，ＣＡ及ＤＮＡ含量为乳腺良恶性病变提供可靠的差别依据，ＮＡ及Ｎ／Ｐ是判别乳腺癌分级和转移的重要因素。
Objective: To study the cytomorpholgy and DNA contents in breast benign and malignant lesions. Methods: Cytomorphological parameters and DNA contents were measured by traditional Feulgen stain and image analysis. Results:a.There were existed significant differences between breast benign and malignant lesions, grade Ⅰand grade Ⅱ or Ⅲ, metastasis and nonmetastasis(P<0 01).b.There were existed obvious difference of DNA content between brease benign and malignant lesions(P<0 01).c.A discriminating formula was established combining cytomorphological parameters and DNA contents. The ratio of back substitution in benign lesion was 100% and in malignant lesion was 98.75%. Conclusion:N/P, NA, CA and DNA content are beliveable basis in discrimination of breast benign and malignant lesions.NA and N/P are important factors of grading and metastasis for breast carcinomas.
出处
《内蒙古医学院学报》
1998年第4期242-244,共3页
Acta Academiae Medicinae Neimongol
