摘要
目的了解北京地区成人雌马酚代谢表型及雌马酚的生理范围,分析雌马酚表型与膳食等生活方式的关系。方法应用现况调查方法,筛选出200名在北京市区居住5年以上、20～72岁成年人,男女各100人。填写问卷获得人口学特征及吸烟饮酒等生活方式,用两天膳食记录法获得膳食营养素摄入量,采用HPLC法分析负荷大豆异黄酮前后尿中雌马酚等大豆异黄酮24h排泄量,计算产雌马酚者比例及其与膳食等因素的关系。结果负荷前雌马酚生理范围0～76.56μmol/24h,产雌马酚者比例为26.8%,负荷后比例提高到60.4%。产雌马酚者与非产生者之间大豆类食品及各种营养素摄入量差异无显著性(P>0.05)。大豆异黄酮摄入量与排泄量呈正相关关系(相关系数为0.49～0.58,P<0.01)。结论在日常膳食条件下,大约有1/4北京成人尿液中能检测到雌马酚,但潜在的产生雌马酚的能力很大。
Objective To investigate the prevalence of equol producers and the physiological range of urinary equol excretion,and also to evaluate relations between equol phenotype and lifestyle among Chinese adults in Beijing.Methods 100 male and 100 female adults participated in a cross-sectional study and provided twice 1d urine samples on regular diet and after 3d soy isoflavone challenge respectively.A health and demographics questionnaire,and 2d food record were completed before the urine collections.Isoflavones and their metabolites in urine were measured to determine equol phenotype by HPLC.Results The physiological range of 24h urinary equol excretion was 0-76.56μmol/24h,and the percentage of the equol producer phenotype was 26.8% on regular diet and 60.4% after soy isofavone challenge,respectively.There was no indication that habitual consumption of soy foods is associated with the equol producer phenotype.The correlations of isoflavone intake from 2d food record with those from urinary isoflavone levels were 0.58 for total isoflavones,0.49 for daidzein,0.56 for genistein,and 0.50 for glycitein （P〈0.01）.Conclusion About one fourth of Chinese adults in Beijing were detected equol excretion in urine under the usually lifestyle.However,equol_producing potential was higher.
出处
《卫生研究》
CAS
CSCD
北大核心
2010年第1期59-64,共6页
Journal of Hygiene Research
基金
国家自然科学基金资助项目(No.30872114)
