摘要
目的:探讨pHGF治疗重症肝炎的作用机理。方法:选用Con A诱导肝损伤的小鼠模型,观察pHGF对肝细胞Fas抗原表达的影响。结果:正常对照未见Fas抗原阳性肝细胞;Con A诱导损伤组见大量表达Fas抗原的干细胞;pHGF处理组Fas抗原阳性细胞表达明显减少。结论:pHGF可能通过抑制肝细胞Fas抗原表达来阻断肝细胞的凋亡。
To investigate the therapeutical actions of pHGF for the treatment of severe hepatitis, the mouse model of Con-A induced hepatocyte demages was used to observe the effect of Fas antigen expressions in liver tissue with the pre-treatment of pHGF. It was found that there was no Fas antigen expression in normal liver tissue, but many liver cells in Con-A induced damages expressed Fas antigen, and the expressions of Fas antigen were reduced significantlly in the pHGF pre-treatment group. It suggests that pHGF might block the development of apoptosis of hepatocytes by inhibiting the Fas antigen expressions in liver cells.
出处
《上海免疫学杂志》
CSCD
北大核心
1998年第6期332-333,339,共3页
Shanghai Journal of Immunology
