摘要
目的：探索吸烟与肝癌发生的病因学联系。方法：利用MEDLINE数据库及中国生物医学文献数据库检索1989年1月—2009年9月国内外公开发表的关于吸烟与肝癌关系的前瞻性研究文献,利用R软件及Meta程序包对检索结果进行荟萃分析。结果：纳入本次荟萃分析的文献共19篇,随访队列总样本量为3 023 558人,累计肝癌病例数为9 525人。与不吸烟者相比,吸烟者经Meta分析综合后的相对危险度（relative risk,RR）值及其95%可信区间（confidence interval,CI）为1.49（1.17－1.92）,提示吸烟与肝癌呈中等程度相关;亚组分析显示,男女性别经Meta分析综合后吸烟的RR值及其95%CI分别为1.53（1.29－1.83）和1.70（1.17－2.48）,差异均有统计学意义。结论：吸烟与男女性肝癌之间存在病因学联系,是肝癌发生的危险因素之一。
Objective：To explore the relationship between tobacco smoking and liver cancer risk.Methods：Cohort studies of cigarette smoking and risk of liver cancer were identified by searching MEDLINE and CBM databases from January 1989 to September 2009.Results from individual studies were combined synthetically by Meta analysis using R software and Meta package.Results：A total of 19 articles were included in our analysis.The cohort totally included 3 023 558 followed-up persons and 9 525 cases of liver cancer patients.The pooled relative risk（RR） of liver cancer was 1.49（95%CI： 1.17-1.92） for smokers compared with non-smokers.The results showed a statistically moderate association between tobacco smoking and the risk of liver cancer.Subgroup analysis indicated that the pooled RRs for smoking were 1.53（95%CI ： 1.29-1.83）for male smokers and 1.70（95%CI ：1.17-2.48）for female smokers,respectively.Conclusion：Tobacco smoking is a risk factor for liver cancer in both males and females.
出处
《肿瘤》
CAS
CSCD
北大核心
2010年第3期247-252,共6页
Tumor
基金
国家科技重大专项基金资助项目(编号:2008ZX10002-015)
关键词
肝肿瘤
吸烟
前瞻性研究
META分析
R软件
Liver neoplasms Smoking Prospective studies Meta-analysis R software
