摘要
目的:探讨抗生素序贯疗法治疗急性肠系膜淋巴结炎的疗效。方法:2005年至2008年住院患儿176例,彩色多普勒超声检查声像符合肠系膜淋巴结炎标准。治疗组(序贯治疗组)98例,给予头孢唑肟或头孢呋辛50～100 mg/(kg.d)静脉滴注,2次/d,至腹痛消失,外周血白细胞恢复正常,疗程3～5 d,改头孢克肟颗粒3～5 mg/(kg.d)口服,2次/d,疗程4～5 d,总疗程7～10 d;对照组(全程静脉给药组)78例给予头孢唑肟或头孢呋辛50～100 mg/(kg.d)静脉滴注,2次/d,疗程7～10 d。结果:两组腹痛消失时间、抗生素应用时间、白细胞恢复正常时间、痊愈率及有效率比较差异无统计学意义(P>0.05),彩色多普勒超声检查各组治疗前后淋巴结大小比较差异有统计学意义(P<0.01),而两组间比较差异无统计学意义(P>0.05);平均治疗费治疗组比对照组少(P<0.01)。结论:有明确细菌感染的肠系膜淋巴结炎儿童,采用抗生素序贯疗法是有效、价廉的治疗方法,易被病儿及家长所接受。
Objective：To explore effects of sequential antibiotic therapy on acute mesentery lymphnoditis. Methods： There were 176 examples from hospitalized patients from 2005 to 2008. The method of color Doppler sonography to check conformed to domestic standard on mesentery lymphnoditis. The treatment group （sequential treatment group） of 98 cases were intravenous-dripped with 50- 100 mg/（kg · d） of Ceftizoxime injection or Cefuroxime injection, two times each day and 3 - 5 days a course till the abdominal pain disappeared and peripheral white blood cells recovered, and then they were administrated with 3 -5 mg/（ kg · d） of Cefixime granules for 4 - 5 days, two times each day and 7 - 10 days a total course; while the control group （the vein medicine group） of 78 eases were intravenous-dripped with 50 - 100 nag/（ kg· d） of Ceftizoxime injection or Cefuroxime injection, two times each day and 7 - 10 days a course. Results： There were no statistical differences between sequential treatment group and the control group in vanishing time of abdominal pain, the applying time of antibiotic, the time of white blood cell recovered to normal, the healing case numbers and effectiveness （ P 〉 0.05 ）. There was significant difference in the size of ganglia lymphatica before and after the treatment （ P 〈 0.01 ） ; but no significant difference between the two groups （P 〉 0.05 ） ; the treatment in the sequential group was less expensive than the control group （P 〈 0.01 ）. Conclusions： It is effective, inexpensive, easily accepted by the baby and the parents using the sequential antibiotic therapy to treat the mesentery lymphnoditis.
出处
《儿科药学杂志》
CAS
2010年第2期16-18,共3页
Journal of Pediatric Pharmacy
关键词
肠系膜淋巴结炎
抗生素序贯疗法
儿童
Mesentery lymphnoditis
Sequential antibiotic therapy
Children
