摘要
目的应用放射性碘(^(131)I)扫描研究含碘造影剂对分化型甲状腺癌患者肺转移病灶^(131)I治疗效果的影响。方法收集82例分化型甲状腺癌肺转移患者的临床资料,根据实施^(131)I治疗前患者是否接受增强CT扫描及其与治疗的间隔时间分为增强CT扫描1组(间隔时间<3个月,n=32)、增强CT扫描2组(间隔时间≥3个月,n=27)和未接受增强CT扫描的阴性对照组(n=23)。^(131)I治疗后,^(131)I扫描观察和分析各组肺转移病灶的摄碘情况并进行疗效评估。结果肺转移病灶^(131)I扫描阳性率比较显示,增强CT扫描1组明显低于增强CT扫描2组和阴性对照组(P<0.05),增强CT扫描2组与阴性对照组比较差异无统计学意义(P>0.05)。三组^(131)I治疗有效率比较差异无统计学意义(P>0.05)。增强CT扫描1、2组肺转移病灶实施首次^(131)I治疗后,^(131)I扫描表现为阴性患者的疗效差于阳性患者。结论^(131)I扫描对甲状腺癌肺转移患者肺内病灶的^(131)I治疗效果具有良好的预测价值;接受^(131)I治疗前3个月内使用含碘造影剂会影响该类患者肺内病灶对^(131)I的摄取。
Objective To explore the effects of iodinated contrast media on therapeutic effect of ^131I in patients with pulmonary metastases from differentiated thyroid carcinoma. Methods The clinical data of 82 patients with pulmonary metastases from differentiated thyroid carcinoma were collected, and were classified into three groups according to the conduction of contrast CT scan： contrast CT scan group 1 （ 〈 3 months of the interval between ^131 I treatment and contrast CT scan, n = 32）, contrast CT scan group 2 （ ≥3 months of the interval between ^131I treatment and contrast CT scan, n = 27） and negative control group （without contrast CT scan, n = 23）. After ^131I treatment, the condition of iodine intake of pulmonary metastatic lesions in each group was observed and analysed by ^131I scan, and the therapeutic effect was evaluated. Results The positive rate of iodine intake of pulmonary metastatic lesions revealed by ^131I scan in contrast CT scan group 1 was significantly lower than those of contrast CT scan group 2 and negative control group（ P 〈 0. 05）, while there was no significant difference between contrast CT scan group 2 and negative control group（P 〉 0.05）. There was no significant difference in therapeutic effect of ^131I treatment among three groups （P 〉 0.05）. However, the therapeutic effect of patients with negative results in initial ^131I treatment was poorer than those with positive results. Conclusion ^131I scan may predict the therapeutic effect of ^131I treatment in patients with pulmonary metastases from differentiated thyroid carcinoma, and the application of iodinated contrast media within 3 months before ^131I treatment may affect the iodine intake of pulmonary metastatic lesions.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第3期253-255,共3页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(30700187)
上海市青年科技启明星计划(08QA14040)~~
关键词
含碘造影剂
甲状腺癌
肺转移
放射性碘
iodinated contrast media
thyroid carcinoma
pulmonary metastasis
radioactive iodine
