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芦荟中蒽衍生物的分离及其抗肿瘤活性的检测 被引量:43

The Anticancerous Activity of Anthracene Derivatives from Aloe
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摘要 目的:建立分离芦荟中蒽衍生物的方法;体外检测蒽衍生物杀伤肿瘤细胞的活性。方法:用乙醚萃取,弃水相,蒸干乙醚,凝胶层析柱分离得蒽衍生物。应用结晶紫染色法,以L929、GM803、MethA、Y99为靶细胞测蒽衍生物的杀伤活性。结果:蒽衍生物具有高效杀伤肿瘤细胞的能力,在0.3μg/ml浓度下对L929细胞杀伤活性(CT值)仍达50%以上。 Objective:We were to establish a method for separating anthracene derivatives from aloe and to investigate their anticancerous activity in vitro. Methods:We applied ether extraction and gel chromatography to separate anthracene derivatives from aloe. GM 803 ,Y 99 , L 929 , and Meth A tumor cell lines were used as target cells to investigate anticancerous activity of anthracene derivatives. Results:The anthracene derivatives were highly effective in killing tumor cells. Their cytotoxic rate (CT) was over 50% for both L 929 and Y 99 cell lines even at a concentration of 0.3 μg/ml. Conclusions:The method for separating anthracene derivatives from aloe was simple and stable. The anthracene derivatives were strongly cytotoxic for both animal and human tumor cells.
出处 《中国医科大学学报》 CAS CSCD 北大核心 1998年第6期571-573,共3页 Journal of China Medical University
关键词 芦荟 蒽衍生物 分离 抗肿瘤活性 aloe anthracene derivative target cell
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