颅内外动脉狭窄支架成形术后血清IL-1β、IL-1Rα的变化及与再狭窄的关系被引量：2

Relationship between levels of serum IL-1β and IL-1Rα and restenosis in patients with intra- and extra-cranial arteriostenosis after stent-assisted angioplasty

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摘要目的分析血清白细胞介素-1β（IL-1β）、白细胞介素-1受体拮抗剂（IL-1Rα）、IL-1Rα／IL-1β比值在颅内外血管狭窄支架成形术后血清中的变化以及与再狭窄的关系．同时探讨IL-1β与IL-1Rα水平之间的相关性。方法选择自2008年4月至2009年3月31例在四川省人民医院神经内科接受颅内外支架成形术的颅内外动脉狭窄患者，就术前、术后1h、1d、3d、5d以及造影复查（术后6～12个月）时血清IL-1β、IL-1Rα和IL-1Rα／IL-1β比值以及血管再狭窄情况进行分析。结果本组31例患者在31根血管上放置31枚支架，随访6～12个月，6例出现了再狭窄（19.35％），超过50％的再狭窄为3例，余3例在10％～30％之间。2组患者术前IL-1β、IL—Rα、IL-1Rα／IL-1β比值差异均无统计学意义（P〉0．05），IL—1β与IL-Rα呈正相关（r=0．444，0．881；P均〈0．05）；术后1h、1d、3d、5d2组患者IL-1β、IL-Rα水平均明显高于术前，差异有统计学意义（P〈0．05）；术后6～12个月复查时2组IL-1β、IL-Rα水平无明显差别（P〉0．05），但再狭窄患者IL-1Rα／IL-1β比值明显低于未再狭窄患者，差异有统计学意义（P〈0．05）；IL—1β与IL-R呈正相关（r=0．531，0．953；P均〈0．05）。结论血清IL-1β、IL-1Rα与支架术后的炎性过程有关，两者的免疫失调状态可能与再狭窄有关。IL-1Rα／IL-1β比值的变化可做为再狭窄监测的指标。 Objective To observe the levels of serum interleukin-1β （IL-1β） and interleukin-1 receptor antagonist （IL- 1Rα）, the IL- 1Rα/IL- 1β ratio and the relationship between the levels of them and the restenosis in patients with intra- and extra-cranial arteriostenosis after stent-assisted angioplasty. Methods Thirty-one patients with cerebral artery stenosis, admitted to our hospital from April 2003 to March 2006, were treated with stent-assistant angioplasty and followed up for 6-12 months. The relationship was analyzed between the restenosis of cerebral artery and both the levels of serum IL-1β, IL-1Rα and the IL-1Rα/IL-1β ratio before and 1 h, 1, 3 and 5 d after stent-assisted angioplasty. Results The condition of 31 stents in 31 blood vessels of cerebral arteries was observed and followed up 6 to 12 months after the operation. Restenosis was noted in 6 （19.3%） with 3 restenosis superior to 50% and 3 restenosis from 10%-30%. No obvious difference of the levels of serum IL-1βand IL-1Rα, the IL-1Rα/IL-1β ratio between restenosis group and non-restenosis group before the operation was found （P〉0.05）; IL-1β and IL-1Rα levels were positively correlated before the operation. The levels of serum IL-1β and IL-1Rα 1h, 1, 3 and 5 d after the operation were superior to those before the operation, respectively（P〈0.05）. The levels of serum IL-1β and IL-1Rα in the restenosis group showed no significant difference to those in the non-restenosis group 6 to 12 months after the operation （P〉0.05）; however, the IL-1Rα/IL-1β ratio in the restenosis group was significantly lower than that in the non-restenosis group（P〈0.05）; positive correlation between the levels oflL-1β and IL-1Rα was observed. Conclusion The levels of serum IL-1β and IL-1Rα were associated with the inflammatory process after the operation and the immune maladjustment of IL-1β and IL-1Rα might be correlative to the restenosis, indicating that the IL-1Rα/IL-1β ratio might be an available index for monitoring the restenosis.

作者韩健郭富强张天王建红吴文斌余能伟

机构地区四川省人民医院神经内科四川省人民医院介入室

出处《中华神经医学杂志》 CAS CSCD 北大核心 2010年第3期277-280,共4页 Chinese Journal of Neuromedicine

关键词白细胞介素-1 受体拮抗剂再狭窄 Interleukin-1 receptor antagonist restenosis Receptor antagonist Restenosis

分类号 R743.3 [医药卫生—神经病学与精神病学]

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参考文献10

1Grewe P, Deneke T, Machraoui A. Acute and chronic tissue response to coronary stent implantation : Pathologic findings in human specimen[J]. J AM Coll Cardiol, 2000, 35(1): 157-163.
2Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators[J]. Circulation, 2003, 108: 2460-2461.
3Li N, Astudillo R, Ivert T, et al. Biphasic pro-thrombotic and inflammatory responses after coronary artery bypass surgery [J]. J Thromb Haemost, 2003, 1: 470-461.
4Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-I receptor antagonist [J]. lnt Rev Immunol, 1998, 16 (5-6): 457-499.
5Kobayashi Y, Yamamoto K, Saido T, et al. Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha[J]. Proc Natl Acad Sci USA, 1990, 87 (14): 5548-5552.
6梁辉,杨期东,高小平,胡美伦.颈动脉狭窄患者支架成形术前后血清C反应蛋白水平变化及辛伐他汀对其的干预作用[J].中华神经医学杂志,2006,5(11):1156-1157. 被引量：1
7李健民,杨希立,李榕生,马明远.冠脉内支架置入在急性心肌梗塞治疗中的应用[J].实用医学杂志,2000,16(11):919-920. 被引量：1
8Arend WP. The balance between IL-1 and IL-1Ra in disease[J]. Cytokine Growth Factor Rev, 2002, 13(4-5): 323.
9Miranda-Malpica E, Martinez-Rios MA, Fragoso JM, et al. The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients [J]. Hum Immunol, 2008, 69(2): 1164121.
10Dinarello CA. Biologic basis for interleukin-1 in disease[J]. Blood, 1996, 87(6): 2095-2147.

二级参考文献6

1李占全,张明,邓重信,赵颖军,栗任军,关汝明,徐桂萍,金元哲,李荣琴,吕跃进,宋大刚.急性心肌梗塞急诊经皮冠状动脉腔内成形术的初步体会(附25例报告)[J].中华心血管病杂志,1995,23(6):424-426. 被引量：33
2Channer KS,Pugh PJ.Interfering with healing:the benefits of intervention during acute myocardial infarction[J].Heart,2001,85:620-622.
3Mulvihill NT,Folry JB.Inflammation in acute coronary syndromes[J].Heart,2002,87:201-204.
4Morrow DA,RidkerPM.C-reactiveprotein,inflammation,and coronary risk[J].Med Clin North Am,2000,84(1):149-161.
5Taku T,Toshio H,Hatsuyo K,et al.Cerivastatin,a HMG-CoA reductive inhibitor,improves endothelial function in elderly diabetics with in 3 days[J].Circulation,2001,104(11):376-379.
6North American Symptomatic Carotid Endarterectomy Trial Collaborators.Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis[J].N Engl J Med,1991,325:445-453.