摘要
目的:评价三金片治疗尿路感染的疗效及安全性。方法:通过网上及手工对电子数据库、参考文献检索三金片治疗尿路感染的随机临床试验,从中提取数据,用循证医学专用软件进行统计分析。结果:13个试验包括1046名患者符合纳入条件。2项试验证实三金片治疗尿路感染分别比羟氨苄青霉素、环丙沙星或诺氟沙星加红霉素效果更好;1项试验显示三金片与加味猪苓汤比较疗效无显著差异;其他试验显示三金片治疗尿路感染与抗生素或中草药相比效果无差异。3项试验显示三金片与中草药或与抗生素联用,与单用抗生素疗效相当。从纳入的试验中没有发现应用三金片的严重不良反应。倒漏斗图示不对称,提示存在发表偏倚,纳入试验的方法学质量存在缺陷。结论:少数试验显示三金片疗效优于抗生素,绝大部分试验显示其与抗生素疗效无明显差异。目前尚无有力证据支持三金片治疗尿路感染优于其它药物。三金片治疗尿路感染临床试验的方法学质量有待提高。
OBJECTIVE： To assess the efficacy and safety of Sanjin tablets in the treatment of urinary tract infection. METHODS： Retrieved from electronic databases and references literatures by on-line or manual way, RCTs about Sanjin tablets in the treatment of urinary tract infection were collected. Related data were obtained and analyzed with evidence-based medical software statistically. RESULTS： 1 046 patients in 13 studies with were included. Two studies showed that Sanjin tablets had better effect than amoxicillin, ciprofloxacin, erythromycin and norfloxacin in the treatment of urinary tract infections. One study showed there was no significant difference in efficacy of Sanjin tablets and Modified juling tang. Other trials showed that there was no difference in efficacy between Sanjin tablets and Chinese herbal medicine, antibiotics. Three trials showed Sanjin tablets combined with Chinese herbal medicine or antibiotics had the same effect with antibiotics alone in the treatment of urinary tract infection. No severe ADR induced by Sanjin tablets was found in included studies. Funnel plot which assumed asymmetry indicated the existence of publication bias and unsatisfactory methodological quality. CONCLUSION： Few trials show efficacy of Sanjin tablets are better than antibiotics. Most of studies show that there is no significant difference between Sanjin tablets and antibiotics. At present no evidence indicate that efficacy of Sanjin tablet is superior to other drugs. The methodological quality of clinical trials of Sanjin tablets for urinary tract infections should be improved.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第11期1034-1036,共3页
China Pharmacy
关键词
三金片
尿路感染
疗效评价
安全性评价
Sanjin tablet
Urinary tract infection
Efficacy evaluation
Safety evaluation
